Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE (3) Stratified by sample type, TLR2 Arg753Gln polymorphism is associated with increased PTB risk, but not with EPTB. 30733958 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE Polymorphisms rs3804099 (TLR2) and rs352139 (TLR9) may also be associated with PTB risk in the Moldavian population but their effect is less consistent across different studies. 30529560 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker disease BEFREE Here we show that differences exist in the expression of a surface protein (Toll-like receptor 2) between macrophages recovered from the sputum of individuals in different diagnostic groups: i.e., infection free, latent tuberculosis infection, and active pulmonary tuberculosis. 29104936 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE Moreover, this study has revealed that person carrying deletion allele in their TLR2Δ22 (-196-174) gene is significantly associated with an increased risk of PTB having b/b or F/f genotypes in BsmI or FokI polymorphisms of VDR gene. 29727015 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE No significant association between polymorphisms of TLR2 and TLR4 with PTB or LTBI was detected. 29924447 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE Genotyping was performed to detect -196 to -174 del polymorphism and G2258A SNP (Arg753Gln, rs5743708) in TLR2 gene and -T1237C (rs5743836) and G2848A (rs352140) SNP in TLR9 gene in patients with pulmonary TB and healthy controls. 29675696 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE There was a significant association between the GA genotype (heterozygous mutant) of TLR2 Arg753Gln polymorphism and the risk of infection with pulmonary TB (p = 0.003, OR = 4.83) and TB peritonitis (p = 0.003, OR = 6.2). 28332241 2017
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker disease BEFREE Since human genetic variation is an important determinant in the outcome of infection with M. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (NRAMP1), Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule1 (ICAM-1), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in a case-control study of pulmonary tuberculosis in Iranian population. 26774366 2016
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE Vitamin D levels and genetic factors, vitamin D receptor (VDR) and Toll like receptor- 2 (TLR-2) gene single nucleotide polymorphisms (SNPs), determine susceptibility to pulmonary tuberculosis. 27207494 2016
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE TLR2 variant genotype 597CC was associated with susceptibility to PTB rather than to TBM. 26722451 2015
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE In TLR2, the frequencies of the CC genotype (OR = 2.262; 95% CI: 1.433-3.570) and C allele (OR = 1.566; 95% CI: 1.223-1.900) in single-nucleotide polymorphism (SNP) rs3804100 were significantly higher in the LTBI group than in the HC group, whereas the GA genotype of SNP rs5743708 was associated with PTB (OR = 6.087; 95% CI: 1.687-21.968). 25928077 2015
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 PosttranslationalModification disease BEFREE This study aimed to determine if TLR2 promoter DNA methylation is associated with pulmonary TB. 25218055 2014
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE Role of Toll-like receptor 2 (-196 to -174) polymorphism in susceptibility to pulmonary tuberculosis in Pakistani population. 23998736 2014
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE TLR2 and TLR4 interaction and a specific VDR haplotype influence protection against PTB in Moroccans patients. 24727508 2014
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE Our data suggest that 597T/C polymorphism, but not Arg677Trp polymorphism, of the TLR-2 gene is a risk factor for susceptibility to PTB in a sample of Iranian population. 23830055 2014
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE TLR2 2258G allele and 2258GG genotype were found to be associated with decreased PTB susceptibility (A vs. G: OR  = 3.02, 95% CI: 2.22-4.12, P<0.001, GA+AA vs. GG: OR  = 2.69, 95% CI = 1.49-4.87, P = 0.001). 24124467 2013
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE TLR2 genetic polymorphisms influence susceptibility to pulmonary TB. 20113509 2010
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB). 20650298 2010
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB). 20797905 2010
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE Microsatellite polymorphisms in intron 2 of the toll-like receptor 2 gene and their association with susceptibility to pulmonary tuberculosis in Han Chinese. 20298136 2010