Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.800 | GeneticVariation | disease | BEFREE | There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1. | 17692928 | 2008 | ||||
|
0.800 | GeneticVariation | disease | BEFREE | This SNP and additional SNPs were discovered through a systematic characterization of the genetic architecture of the TPH2 gene for further genetic and functional investigations of its relationship to major depression and other psychopathology. | 18180764 | 2008 | ||||
|
0.800 | Biomarker | disease | MGD | Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. | 18212115 | 2008 | ||||
|
0.800 | GeneticVariation | disease | BEFREE | Genetic variations in the TPH2 gene have been associated with an increased risk for major depression and suicidal behavior. | 17251907 | 2007 | ||||
|
0.800 | Biomarker | disease | BEFREE | Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent. | 16806105 | 2007 | ||||
|
0.800 | GeneticVariation | disease | BEFREE | Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. | 17217922 | 2007 | ||||
|
0.800 | Biomarker | disease | CTD_human | Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. | 17950541 | 2007 | ||||
|
0.800 | AlteredExpression | disease | BEFREE | Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. | 16192985 | 2006 | ||||
|
0.800 | GeneticVariation | disease | BEFREE | Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. | 15629698 | 2005 | ||||
|
0.800 | GeneticVariation | disease | BEFREE | Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system. | 15124006 | 2004 |