Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE The present findings suggest that major depression is frequent in SZ patients and that increased CRP levels are associated with non-remission under antidepressants in this population. 31676465 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE Multivariate logistic regression analysis revealed that male sex, high blood pressure, hypertriglyceridemia, BMI ≥30kg/m², age ≥50 years, sleep duration <6.5 hours, C-reactive protein ≥4.5mg/L, Beck Depression Inventory >12, and apnea-hypopnea index ≥5/h were significant risk factors of type 2 diabetes in major depression. 29246639 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Baseline serum C-reactive protein levels may predict antidepressant treatment responses in patients with major depressive disorder. 30878656 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE C-reactive protein, diet quality and physical activity did not mediate the effect of obesity on major depressive disorder, and C-reactive protein mediated about 25% of the effect of major depressive disorder on adiposity. 31800914 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE While cross-sectional associations of inflammatory markers interleukin-6 (IL-6) and C-reactive protein with major depressive disorder are well established, evidence for longitudinal associations mostly comes from studies on depression symptoms, not diagnoses. 30819515 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE CRP, DII, and WBC were associated with MD.No associations were found for IgE. 30699847 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Increased plasma nesfatin-1 levels may be associated with corticosterone, IL-6, and CRP levels in patients with major depressive disorder. 29427582 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE Prior studies suggest that the inflammatory biomarker c-reactive protein (CRP) holds promise for predicting antidepressant response in patients with major depressive disorder. 30102967 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE The aim of this study was to investigate the relationship between quality of life (QoL) (physical and mental health, assessed by the SF-36) and chronic inflammation assessed using C-reactive protein (CRP) in patients with current major depressive disorder. 29156363 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE This study examined circulating concentrations of C-reactive protein (CRP), plasma tryptophan, kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) and whole blood mRNA expression of IDO in patients with major depressive disorder (MDD) compared with healthy controls (HC). 29787958 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE Additionally, our findings suggest a causal relationship between increased inflammation and high cholesterol in depression, as a single infusion of infliximab reduced cholesterol in TRD patients with high CRP compared to placebo. 30249443 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression. 28257825 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Patients with MD exhibited higher levels of CRP, higher neutrophil and monocyte counts, lower IL-10 levels and reduced LPS-stimulated IL-6 production compared to controls (P<0.001-0.045). 28509904 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Baseline CRP levels relate differentially to antidepressant treatment outcomes in persons with major depressive disorder. 28187400 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease PSYGENET Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. 22683764 2012
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease PSYGENET Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder. 22832853 2012