FGFR1 is implicated in synapse formation in the hippocampus, and alterations in the expression of <i>Fgfr1</i> and its ligand, <i>Fgf2</i> accompany major depression.
As a result, 99 genes were listed as the differentially expressed genes in major depression, of which several genes such as FGFR1, NCAM1, and CAMK2A were of interest.
We determined the distribution of hippocampal FGF-2 and its receptor (FGFR1) mRNA in post-mortem brains of people who suffered from major depression, bipolar disorder and schizophrenia and those of controls.