Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease BEFREE Selective inhibition of FKBP51 has emerged as possible novel treatment for diseases like major depressive disorder, obesity, chronic pain, and certain cancers. 31800244 2020
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE Effects of early life adversity and FKBP5 genotype on hippocampal subfields volume in major depression. 30986730 2019
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE This is the first study to investigate interactions between FKBP5 variants and a range of environmental stressors in adolescents with a clinical diagnosis of MD. 30953930 2019
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE The aim of the present study was to review and conduct a meta-analysis on the results from published studies examining interaction between FKBP5 gene variants and early-life stress and their associations with stress-related disorders such as major depression and PTSD. 28850857 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease BEFREE Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression. 29182159 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease BEFREE Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5). 28989100 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder. 30107269 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) in the FKBP5 gene are associated with altered hypothalamus-pituitary-adrenal (HPA) axis function, changes in the structure and function of several cognitive brain areas, and increased susceptibility to post-traumatic stress disorder, major depression, bipolar disorder and suicidal events. 28002634 2017
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 PosttranslationalModification disease BEFREE Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder. 28198448 2017
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE The FKBP5 polymorphism rs1360780 influences the effect of an algorithm-based antidepressant treatment and is associated with remission in patients with major depression. 26645208 2016
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease PSYGENET The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. 25436518 2015
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease PSYGENET Accumulation of cytoplasmic glucocorticoid receptor is related to elevation of FKBP5 in lymphocytes of depressed patients. 25355489 2015
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease BEFREE The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. 25436518 2015
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are associated with DNA methylation and FKBP5 gene expression after psychosocial stress. 25522420 2014
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease PSYGENET In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are associated with DNA methylation and FKBP5 gene expression after psychosocial stress. 25522420 2014
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease PSYGENET We have observed an association between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) and major depressive disorder (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively), but not bipolar disorder. 24856550 2014
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE We have observed an association between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) and major depressive disorder (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively), but not bipolar disorder. 24856550 2014
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. 23406438 2013
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease PSYGENET Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders. 23861224 2013
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 AlteredExpression disease BEFREE The aim of this study was to comprehensively assess the role of genetic variation in FKBP5, identified by both Sanger and Next Generation DNA resequencing, as well as genome-wide single nucleotide polymorphisms (SNPs) associated with FKBP5 expression in the response to the selective serotonin reuptake inhibitor (SSRI) treatment of major depressive disorder. 23324805 2013
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease BEFREE Several genes, including FKBP5 and DUSP1, previously associated with the pathophysiology of major depression, were found to be reliable markers of GR-activation. 22237309 2012
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) in the FKBP5 gene associate with increased recurrence of depressive episodes, increased susceptibility to post-traumatic stress disorder, bipolar disorder, attempt of suicide, and major depressive disorder in HIV patients. 21935478 2011
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 AlteredExpression disease BEFREE Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals. 20726698 2010
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 Biomarker disease BEFREE Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder. 19545546 2009
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.400 AlteredExpression disease BEFREE Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. 19199039 2009