Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE This study suggests that in patients who have experienced AIS, there is no significant relationship between major depression and basal proinflammatory cytokines (TNF-α, IL-1 β, IL-18), BDNF, and NSE. 31142907 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine considered to be implicated in the pathogenesis of major depressive disorder, is a critical regulator of neuronal cell fate. 30840161 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE The up-regulation of pro-inflammatory agents, amongst them tumor necrosis factor (TNF), may represent low-grade inflammation in major depression. 31622870 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Serum Levels of Tumor Necrosis Factor-α and Loudness Dependence of Auditory Evoked Potentials at Pretreatment and Posttreatment in Patients with Major Depressive Disorder. 31561419 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Effect of selective serotonin reuptake inhibitor on prefrontal-striatal connectivity is dependent on the level of TNF-α in patients with major depressive disorder. 30520409 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE The aim of the present study was to evaluate the plasma nesfatin-1, corticosterone, and inflammatory cytokine (IL-6, CRP, and TNF-α) concentrations cross-sectionally in patients with major depressive disorder. 29427582 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE TNF-α expression was examined in the dorsolateral prefrontal cortex of the postmortem brains of persons with and without major depressive disorder who died by suicide and of persons with major depressive disorder who died of causes other than suicide. 29361849 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Low tumor necrosis factor-α levels predict symptom reduction during electroconvulsive therapy in major depressive disorder. 29670819 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Effects of tumor necrosis factor-α polymorphism on the brain structural changes of the patients with major depressive disorder. 30310056 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE In the present study, we chose TNF-α and BDNF because reduction of TNF-α and rise in BDNF levels are linked with improvement in major depressive disorder. 28833192 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review. 27187381 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease PSYGENET A whole genome expression analysis of peripheral blood mononuclear cells yielded 12 protein-coding genes (ADM, APBB3, CD160, CFD, CITED2, CTSZ, IER5, NFKBIZ, NR4A2, NUCKS1, SERTAD1, TNF) that were differentially expressed between 29 unmedicated depressed patients with a mood disorder (8 bipolar disorder, 21 major depressive disorder) and 24 healthy controls (HCs). 23064081 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease PSYGENET TNF-alpha -308G>A polymorphism is associated with suicide attempts in major depressive disorder. 23608119 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease PSYGENET Venlafaxine inhibits the upregulation of plasma tumor necrosis factor-alpha (TNF-α) in the Chinese patients with major depressive disorder: a prospective longitudinal study. 22683211 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Venlafaxine inhibits the upregulation of plasma tumor necrosis factor-alpha (TNF-α) in the Chinese patients with major depressive disorder: a prospective longitudinal study. 22683211 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease PSYGENET Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. 22683764 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease PSYGENET Poor replication of candidate genes for major depressive disorder using genome-wide association data. 20351714 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE An activation of the TNF-alpha system could contribute to the development of MD in the elderly. 19618378 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE One hundred five patients with hepatitis C, initially without active major depression (major depressive disorder), were treated with interferon alfa and then prospectively monitored using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, the Beck Depression Inventory II, the Anger Irritability and Assault Questionnaire, and circulating TNF-alpha levels. 20661026 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Increased soluble tumor necrosis factor-alpha receptors in patients with major depressive disorder. 19175760 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Our findings suggested that the investigated TNF-alpha SNP may: (1) affect MD susceptibility; (2) be involved both in AD and MD development, but probably with a distinct role in the two pathologies. 19836613 2009