Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.050 AlteredExpression disease BEFREE We assessed the urticaria activity score (UAS), total antioxidant status (TAS), glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), albumin, alpha1, alpha2, beta1 beta2, gamma globulins, c-reactive protein (CRP) and hematologic numeration. 28351163 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.050 AlteredExpression disease BEFREE A set of initial clinical criteria have been drawn up which it is recommended should be fulfilled before a patient is tested: at least three recurrent bouts, age at disease onset < 20 years and elevated levels of C-reactive protein, especially in individuals with urticaria and moderate fever. 21109514 2011
Entrez Id: 710
Gene Symbol: SERPING1
SERPING1
0.050 Biomarker disease BEFREE Criteria were developed for the diagnosis of HAE with normal C1INH in patients with recurrent angioedema in the absence of concurrent urticaria. 23394603 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.030 GeneticVariation disease BEFREE Thus, we aimed to investigate whether there is an association between ACE I/D polymorphism and chronic ordinary urticaria. 18181977 2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.030 Biomarker disease BEFREE Angiotensin-converting enzyme (ACE) inhibitor associated angioedema was detected in 39 subjects (17%) of 231 consecutive patients examined in the last 5 years at our out-patient clinic for symptoms of angioedema without urticaria. 10604520 1999
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.030 GeneticVariation disease BEFREE It can present with urticaria or anaphylaxis and is usually associated with angiotensin-converting enzyme inhibitors (ACEis), complement deficiencies, or the side effects of tissue plasminogen activator (tPA). 29850387 2018
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.030 Biomarker disease BEFREE The aim of this study was to compare the clinical features, total eosinophil count, serum levels of interleukin (IL)-18, IL-18 binding protein (BP), IL-1 receptor-like (RL) 1, and IL-33 and compare with tryptase to examine if any differences could be found between patients who experienced anaphylaxis and urticaria. 31837215 2019
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.030 Biomarker disease BEFREE As frequent attacks of urticaria and associated arthralgia had a debilitating effect on the child's lifestyle, a trial of IL-1-receptor antagonist (anakinra) was instituted. 17300660 2007
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.030 Biomarker disease BEFREE IL-1 receptor antagonist anakinra is usually highly efficient in Schnitzler syndrome (SS), a rare inflammatory condition associating urticaria, fever, and IgM monoclonal gammopathy. 23527164 2013
Entrez Id: 140767
Gene Symbol: NRSN1
NRSN1
0.020 AlteredExpression disease BEFREE HIV+ controls (n = 12) had no detectable HIV-1 DNA, RNA, or p24 in the CNS; latent HIV+ cases (n = 10) showed high levels of HIV-1 DNA but no HIV RNA or p24; and HIVE cases (n = 10) had high levels of HIV-1 DNA, RNA, and p24. 23486877 2013
Entrez Id: 968
Gene Symbol: CD68
CD68
0.020 AlteredExpression disease BEFREE IL-1beta- or TNF-alpha-positive cells were almost restricted to CD68-positive macrophages/microglia and mild expression of these cytokines by astrocytes was observed in two cases with severe HIVE. 19170891 2009
Entrez Id: 928
Gene Symbol: CD9
CD9
0.020 Biomarker disease BEFREE Single- and double-labeled studies using antibodies against CD14, CD16, CD68, proliferating cell nuclear antigen (PCNA), Ki-67, von Willebrand factor, and HIV-1 p24 were performed using brain tissue from patients with HIVE, HIV-1 infection without encephalitis, and seronegative controls. 15161643 2004
Entrez Id: 928
Gene Symbol: CD9
CD9
0.020 AlteredExpression disease BEFREE HIV+ controls (n = 12) had no detectable HIV-1 DNA, RNA, or p24 in the CNS; latent HIV+ cases (n = 10) showed high levels of HIV-1 DNA but no HIV RNA or p24; and HIVE cases (n = 10) had high levels of HIV-1 DNA, RNA, and p24. 23486877 2013
Entrez Id: 968
Gene Symbol: CD68
CD68
0.020 AlteredExpression disease BEFREE In opiate addicts, there was generally higher baseline expression of CD68 and HLA-D in HIV negatives, and lower expression in HIV and HIVE, compared to individuals without opiate abuse. 22797933 2012
Entrez Id: 3002
Gene Symbol: GZMB
GZMB
0.020 AlteredExpression disease BEFREE Granzyme B and H precursor gene expression was up-regulated and interleukin (IL)-12A precursor, a maturation factor for natural killer cells and CTLs, was down-regulated in HIVE versus HIVnE brain. 16966218 2006
Entrez Id: 4827
Gene Symbol: NM
NM
0.020 Biomarker disease BEFREE Interleukin-6 is a gp130 utilizing cytokine that is consistently associated with allergic diseases like asthma and urticaria in humans where mast cells are known to play a critical role. 29410184 2018
Entrez Id: 3002
Gene Symbol: GZMB
GZMB
0.020 AlteredExpression disease BEFREE In HIV+ subjects without HIVE, shorter HO-1 (GT)n alleles associated significantly with lower expression of brain type I interferon response markers (MX1, ISG15, and IRF1) and T-lymphocyte activation markers (CD38 and GZMB). 29510721 2018
Entrez Id: 11261
Gene Symbol: CHP1
CHP1
0.020 AlteredExpression disease BEFREE HIV+ controls (n = 12) had no detectable HIV-1 DNA, RNA, or p24 in the CNS; latent HIV+ cases (n = 10) showed high levels of HIV-1 DNA but no HIV RNA or p24; and HIVE cases (n = 10) had high levels of HIV-1 DNA, RNA, and p24. 23486877 2013
Entrez Id: 140767
Gene Symbol: NRSN1
NRSN1
0.020 Biomarker disease BEFREE Single- and double-labeled studies using antibodies against CD14, CD16, CD68, proliferating cell nuclear antigen (PCNA), Ki-67, von Willebrand factor, and HIV-1 p24 were performed using brain tissue from patients with HIVE, HIV-1 infection without encephalitis, and seronegative controls. 15161643 2004
Entrez Id: 115482709
Gene Symbol: H3P19
H3P19
0.020 AlteredExpression disease BEFREE HIV+ controls (n = 12) had no detectable HIV-1 DNA, RNA, or p24 in the CNS; latent HIV+ cases (n = 10) showed high levels of HIV-1 DNA but no HIV RNA or p24; and HIVE cases (n = 10) had high levels of HIV-1 DNA, RNA, and p24. 23486877 2013
Entrez Id: 967
Gene Symbol: CD63
CD63
0.020 Biomarker disease BEFREE Given the important role of basophils in the pathogenesis of urticaria and that CD63 serves as a useful marker for basophil activation and detecting, CD63 expression of basophils is a reliable tool for diagnosing allergy and hypersensitivity reactions to different allergens; the objective of this study was to investigate whether the level of basophil CD63 expression is correlated with allergen sensitization, serum autoreactivity and basophil reactivity in patients with CSU. 27518369 2017
Entrez Id: 3497
Gene Symbol: IGHE
IGHE
0.020 Biomarker disease BEFREE A PK/PD relationship curve suggests that dermal concentrations above 6.8 μM should lead to approximately 90% inhibition of histamine release from skin mast cells following activation of the Fc fragment of IgE receptor 1a, implicating a potential use for the compound in skin mast cell diseases such as urticaria. 30735243 2019
Entrez Id: 847
Gene Symbol: CAT
CAT
0.020 AlteredExpression disease BEFREE We assessed the urticaria activity score (UAS), total antioxidant status (TAS), glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), albumin, alpha1, alpha2, beta1 beta2, gamma globulins, c-reactive protein (CRP) and hematologic numeration. 28351163 2017
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.020 AlteredExpression disease BEFREE SOD activity and expression were increased in all types of non-immediate reactions (urticaria, maculopapular exanthema and toxic epidermal necrolysis). 16879248 2006
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.020 Biomarker disease BEFREE Single- and double-labeled studies using antibodies against CD14, CD16, CD68, proliferating cell nuclear antigen (PCNA), Ki-67, von Willebrand factor, and HIV-1 p24 were performed using brain tissue from patients with HIVE, HIV-1 infection without encephalitis, and seronegative controls. 15161643 2004