Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7249
Gene Symbol: TSC2
TSC2
0.550 Biomarker group BEFREE In this study, we demonstrated that osteopontin (OPN) was dramatically reduced by loss of TSC1/TSC2 complex in Tsc2-null mouse embryonic fibroblasts (MEFs), rat uterine leiomyoma-derived Tsc2-deficient cells, genetically modified mouse TSC models, and clinical samples. 28013293 2017
Entrez Id: 7249
Gene Symbol: TSC2
TSC2
0.550 Biomarker group BEFREE TSC2-deficient Eker rat uterine leiomyoma ELT3 cells were stably transfected with empty vector or plasmid for the expression of TSC2. 27458154 2016
Entrez Id: 7249
Gene Symbol: TSC2
TSC2
0.550 Biomarker group BEFREE Importantly, rapamycin treatment did not affect the expression of AdPLA2 and the production of PGE2 by TSC2-deficient mouse embryonic fibroblast (Tsc2-/-MEFs), rat uterine leiomyoma-derived ELT3 cells, and LAM patient-associated renal angiomyolipoma-derived "mesenchymal" cells. 25347447 2014
Entrez Id: 7249
Gene Symbol: TSC2
TSC2
0.550 AlteredExpression group BEFREE To examine whether down-regulation of tuberin, a TSC2 gene product, is present in human uterine leiomyoma, we analyzed leiomyoma and matched myometrium tissues from 22 Chinese patients with Western blotting and real-time polymerase chain reaction analyses, and found that the expression of tuberin was significantly increased in leiomyoma tissues compared with matched myometrium tissues with inhibition of both the mammalian target of rapacmycin pathway and mitogen-activated protein kinase pathways. 21145542 2011
Entrez Id: 7249
Gene Symbol: TSC2
TSC2
0.550 AlteredExpression group BEFREE These rats develop uterine leiomyomata as a consequence of loss of Tsc2 function and up-regulation of mTOR signaling. 19622772 2009
Entrez Id: 7249
Gene Symbol: TSC2
TSC2
0.550 Biomarker group CTD_human Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance. 15937110 2005
Entrez Id: 7249
Gene Symbol: TSC2
TSC2
0.550 Biomarker group MGD
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 GeneticVariation group BEFREE Myoid hamartoma of the breast may be pathogenetically related to benign connective tissue tumors with HMGA2 rearrangements, such as pulmonary hamartomas, lipomas, myolipomas, and leiomyomas. 31659109 2020
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 GeneticVariation group BEFREE While alterations of MED12 and HMGA2 are most common in uterine leiomyomas, a range of other genetic pathways have been described. 31027501 2019
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE Relations between EPO mRNA expression, MED12 exon 2 mutation, and HMGA1/HMGA2 mRNA expression levels in leiomyoma samplings, in addition to effects of estrogen (E) on EPO mRNA expression in cultures of leiomyoma cells. 30554729 2019
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE Hydropic leiomyoma: a distinct variant of leiomyoma closely related to HMGA2 overexpression. 30292626 2019
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE HMGA2 overexpression in ULM is not only related to tumor development but also plays a role in controlling cellular proliferation through the AKT pathway. 29790226 2018
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE In addition, the common clonal origin of tumors overexpressing HMGA2 mRNA and its expression in few myometrial tissue points to HMGA2 up-regulation as an early event in leiomyoma tumorigenesis. 30017537 2018
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE Furthermore, five miRNAs were described as potential regulators of HMGA2 expression in UL. 30376129 2018
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 Biomarker group BEFREE In our study, 60% of cases showed nuclear staining for HMGA2 by immunohistochemistry, which supports the possibility that these tumors harbor aberration of the HMGA2 gene, as seen in lipomas and leiomyomas elsewhere. 27635945 2017
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE MED12 mutations were the most common alterations in conventional and mitotically active leiomyomas and leiomyosarcomas, while leiomyomas with bizarre nuclei were most often FH deficient and cellular tumors showed frequent HMGA2 overexpression. 28592321 2017
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE In the leiomyomas with 12q rearrangements, both HMGA2 and PLAG1 were expressed whereas in the tumors with 8q aberrations, only PLAG1 was expressed. 28591699 2017
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 Biomarker group BEFREE The higher amount of extracellular matrix in MED12-LM than HMGA2-LM was partially due to the high concentration of collagen-producing TAF. 29055020 2017
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE RAD51 paralog B (RAD51B), the preferential translocation partner of HMGA2, was up-regulated in MED12 mutant lesions, suggesting a role for this gene in the genesis of leiomyomas. 26787895 2016
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 Biomarker group BEFREE The recent discovery of somatic mutations involving mediator subunit complex 12 (MED12) or high-mobility group AT-hook 2 (HMGA2) in the majority of fibroids and the links to their pathophysiology were also significant advances. 26107781 2015
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 Biomarker group BEFREE Our work demonstrates that the truncated/short form of HMGA2 induces myometrial cell transformation toward putative tumor-initiating leiomyoma cells and opens up new possibilities to understand the origin of leiomyomas and the development of new therapeutic approaches. 25542836 2015
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE All leiomyomas with HMGA2 overexpression also revealed an activation of PLAG1 in the absence of detectable chromosome 8 abnormalities affecting the PLAG1 locus. 24516594 2014
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 GeneticVariation group BEFREE Cells of one genetic subtype of UL, i.e., those with rearrangements of the high mobility AT-hook 2 protein gene (HMGA2), seem to be able to proliferate in vitro for many passages whereas tumor cells from the much more frequent MED12-mutated lesions barely survive even the first passages. 24446130 2014
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 GeneticVariation group BEFREE Whereas 70.0% (14/20) HMGA2-mutated fibroids made their appearance as solitary nodules, 85.5% (153/179) MED12-mutated fibroids occurred as multiple nodules as a rule of independent clonal origin, as reflected by different MED12 mutations. 25272295 2014
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.500 AlteredExpression group BEFREE When we further examined HMGA2 expression in all leiomyomas and leiomyosarcomas, we found that HMGA2 overexpression was exclusively present in those leiomyomas with no MED12 mutation, accounting for 10.1% (18/178) of total leiomyomas and 40% (18/45) of non-MED12 mutant leiomyomas. 24390224 2014