Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.500 Biomarker group CTD_human Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. 17569694 2007
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.500 Biomarker group RGD Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. 17569694 2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been speculated to be and extensively investigated as a risk factor for various vascular diseases, including intracerebral hemorrhage (ICH). 26757363 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Prevalence of variants in methylenetetrahydrofolate reductase and the severity of pulmonary vascular disease. 25304246 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Methylenetetrahydrofolate reductase (MTHFR) gene variants are associated with thrombophilia and vasculopathy that may result in oral ulceration. 23665953 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Methylenetetrahydrofolate reductase (MTHFR) gene variants have been associated with vasculopathy that has been linked to diabetic neuropathy. 23901246 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Mutations in the methylenetetrahydrofolate reductase (MTHFR) enzyme, which is involved in homocysteine metabolism, have been investigated as potential vascular disease risk factors. 24310797 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Livedoid vasculopathy in a patient with lupus anticoagulant and MTHFR mutation: treatment with low-molecular-weight heparin. 22592843 2012
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. 23285280 2012
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Blood samples from 70 patients with vascular disease and 70 healthy controls were analyzed for plasma homocysteine levels (chemiluminescent immunoassay) and for the presence of MTHFR C677T (polymerase chain reaction analysis). 22375042 2012
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE To investigate the influence of MTHFR polymorphism on vascular disease risks in young Japanese females, we determined dietary intakes, serum folate and tHcy, and examined the influence of MTHFR 677C>T polymorphism in healthy junior and high school students (n=192, 12-18y). 22507617 2012
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Methylenetetrahydrofolate reductase (MTHFR) polymorphisms are associated with thrombophilia and vasculopathy that may result in cutaneous ulceration. 21482894 2011
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 Biomarker group CTD_human MTHFR 677C/T polymorphism is associated with the risk of vascular diseases due to hyperhomocysteinemia. 19646848 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE MTHFR 677C/T polymorphism is associated with the risk of vascular diseases due to hyperhomocysteinemia. 19646848 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The substitution of cytosine (C) by thymine (T) at nucleotide 677 of the methylenetetrahydrofolate reductase (MTHFR) gene, which converts an alanine to a valine residue, is a frequent polymorphism with reduced specific activity, associated with moderate increase in plasma homocysteine levels (tHcy) and risk of vascular diseases. 18855261 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Mutations or polymorphisms in the gene of the enzyme methylenetetrahydrofolate reductase (MTHFR), as C677T, A1298C and G1793A, are associated with hyperhomocysteinemia and possibly with elevated risk for vascular diseases. 17966140 2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. 16564429 2006
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE CBS 844ins68 lowers tHcy and negates the raising effect of MTHFR C(677)T in healthy subjects, but it is unclear if this is the case in subjects at high risk of vascular disease. 16259797 2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Two common polymorphisms (677C>T and 1298A>C) in the gene coding for MTHFR have been shown to reduce MTHFR enzyme activity and were associated with the susceptibility to different disorders, including vascular disease, neural tube defects and lymphoid malignancies. 15921520 2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene, one of the key enzymes catalyzing remethylation of homocysteine, may play a role in the development of not only vascular disease but also diabetic microangiopathies. 15126006 2004
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. 15053827 2004
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE We found raised median tHcy levels in all patient groups vs. controls (p < 0.05), with odds ratios (95% CI) for vascular disease among patients with HHcy (defined as > 15 micromol/l) of 3.9 (0.6 - 14.3), 4.8 (1.2 - 18.8) and 15.8 (2.8 - 87.3) respectively. tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the MTHFR C677T homozygous substitution. 14698652 2003
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Standard methods were used to measure biochemical variables and to characterize vascular disease and MTHFR genotype. 12049616 2002
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Although hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene polymorphism are accepted risk factors for cardiovascular disease, their association with micro angiopathy or blood pressure in diabetic patients is still being debated. 12242465 2002
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia and occlusive retinal vascular disease in type 2 diabetic and non-diabetic subjects. 12356186 2002