Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.440 GeneticVariation disease BEFREE Her ECG revealed QT-prolongation associated with LQT2-specific T-U wave patterns, T wave alternans, long QT-dependent torsade de pointes (TdP) and ventricular fibrillation (VF). 29037423 2019
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.440 Biomarker disease GENOMICS_ENGLAND Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles. 29085299 2017
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.440 GeneticVariation disease BEFREE This study characterized the properties of a novel KCNH2 mutation discovered in a LQT2 patient resuscitated from a ventricular fibrillation arrest. 21483829 2011
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.440 GeneticVariation disease BEFREE Oral quinidine is effective in suppressing the gain of function in IKr responsible for some cases of short QT syndrome with a mutation in HERG and thus restoring normal rate dependence of the QT interval and rendering ventricular tachycardia/ventricular fibrillation noninducible. 15673388 2005
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.440 GeneticVariation disease BEFREE A decrease of IKr or IKs by mutations in either HERG, KvLQT1, or KCNE family results in inherited long QT syndrome (LQTS) with high risk for Torsades de pointes (TdP)-type polymorphic ventricular tachycardia and ventricular fibrillation. 14769199 2004
Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
0.440 Biomarker disease HPO
Entrez Id: 3764
Gene Symbol: KCNJ8
KCNJ8
0.420 GeneticVariation disease BEFREE KCNJ8 sequence variations are traditionally associated with J-wave syndromes, involving ventricular fibrillation and sudden cardiac death. 24176758 2013
Entrez Id: 3764
Gene Symbol: KCNJ8
KCNJ8
0.420 Biomarker disease CTD_human Ventricular fibrillation with prominent early repolarization associated with a rare variant of KCNJ8/KATP channel. 19120683 2009
Entrez Id: 3764
Gene Symbol: KCNJ8
KCNJ8
0.420 GeneticVariation disease BEFREE Ventricular fibrillation with prominent early repolarization associated with a rare variant of KCNJ8/KATP channel. 19120683 2009
Entrez Id: 3764
Gene Symbol: KCNJ8
KCNJ8
0.420 Biomarker disease HPO
Entrez Id: 9992
Gene Symbol: KCNE2
KCNE2
0.410 Biomarker disease CTD_human MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. 10219239 1999
Entrez Id: 9992
Gene Symbol: KCNE2
KCNE2
0.410 GeneticVariation disease BEFREE Three missense mutations associated with long QT syndrome and ventricular fibrillation are identified in the gene for MiRP1. 10219239 1999
Entrez Id: 9992
Gene Symbol: KCNE2
KCNE2
0.410 Biomarker disease HPO
Entrez Id: 6336
Gene Symbol: SCN10A
SCN10A
0.400 Biomarker disease CTD_human Genetic variation in SCN10A influences cardiac conduction. 20062061 2010
Entrez Id: 6336
Gene Symbol: SCN10A
SCN10A
0.400 Biomarker disease HPO
Entrez Id: 6508
Gene Symbol: SLC4A3
SLC4A3
0.300 Biomarker disease GENOMICS_ENGLAND Emerging therapeutic targets in the short QT syndrome. 29697308 2018
Entrez Id: 2056
Gene Symbol: EPO
EPO
0.300 Therapeutic disease CTD_human Erythropoietin pretreatment protects against acute chemotherapy toxicity in isolated rat hearts. 18156309 2008
Entrez Id: 10060
Gene Symbol: ABCC9
ABCC9
0.300 Biomarker disease RGD Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction. 15115899 2004
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
0.300 Biomarker disease CTD_human Ventricular fibrillation after intrapleural urokinase. 9083243 1997
Entrez Id: 3630
Gene Symbol: INS
INS
0.300 Therapeutic disease CTD_human Postoperative ventricular arrhythmias caused by isoproterenol. Conversion with insulin. 5348156 1969
Entrez Id: 10060
Gene Symbol: ABCC9
ABCC9
0.300 Biomarker disease HPO
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.210 Biomarker disease BEFREE LVEDV >158 mL and no use of angiotensin-converting-enzyme inhibitor/angiotensin receptor blocker were independent predictors of recurrences of VT/VF in ICM patients but not in DCM patients. 30038875 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.210 Therapeutic disease RGD Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat. 25663023 2015
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.200 GeneticVariation disease BEFREE A few studies reported the association of SCN5A variant with ventricular tachycardia (VT)/ventricular fibrillation (VF) complicating AMI. 31751991 2020
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.200 GeneticVariation disease BEFREE Family history of sudden cardiac death (SCD), prior syncope, spontaneous type 1 Brugada electrocardiogram (ECG), inducible ventricular fibrillation at electrophysiological study, and SCN5A mutations were present in 26%, 49%, 65%, 28%, and 58% of patients, respectively. 30975291 2019