Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6092
Gene Symbol: ROBO2
ROBO2 		0.440 GeneticVariation disease BEFREE ROBO2 gene variants in children with primary nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia. 27002985 2016
Entrez Id: 6092
Gene Symbol: ROBO2
ROBO2 		0.440 GeneticVariation disease BEFREE Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux. 23536131 2013
Entrez Id: 6092
Gene Symbol: ROBO2
ROBO2 		0.440 GeneticVariation disease BEFREE Recently, two heterozygous ROBO2 missense mutations were identified in two families with primary vesicoureteral reflux occurring in combination with congenital anomalies of the kidney and urinary tract (VUR/CAKUT). 18235093 2008
Entrez Id: 6092
Gene Symbol: ROBO2
ROBO2 		0.440 GeneticVariation disease LHGDN Recently, two heterozygous ROBO2 missense mutations were identified in two families with primary vesicoureteral reflux occurring in combination with congenital anomalies of the kidney and urinary tract (VUR/CAKUT). 18235093 2008
Entrez Id: 6092
Gene Symbol: ROBO2
ROBO2 		0.440 Biomarker disease LHGDN Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. 17357069 2007
Entrez Id: 6092
Gene Symbol: ROBO2
ROBO2 		0.440 Biomarker disease BEFREE Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. 17357069 2007
Entrez Id: 6092
Gene Symbol: ROBO2
ROBO2 		0.440 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 6092
Gene Symbol: ROBO2
ROBO2 		0.440 Biomarker disease HPO
Entrez Id: 7148
Gene Symbol: TNXB
TNXB 		0.410 GeneticVariation disease BEFREE TNXB mutations can cause vesicoureteral reflux. 23620400 2013
Entrez Id: 64321
Gene Symbol: SOX17
SOX17 		0.410 GeneticVariation disease BEFREE We have identified mutations in SOX17, an HMG-box transcription factor and Wnt signaling antagonist, in eight patients with CAKUT (seven vesico-ureteric reflux, one pelvic obstruction). 20960469 2010
Entrez Id: 7148
Gene Symbol: TNXB
TNXB 		0.410 Biomarker disease HPO
Entrez Id: 64321
Gene Symbol: SOX17
SOX17 		0.410 Biomarker disease CTD_human
Entrez Id: 7148
Gene Symbol: TNXB
TNXB 		0.410 Biomarker disease CTD_human
Entrez Id: 64321
Gene Symbol: SOX17
SOX17 		0.410 Biomarker disease HPO
Entrez Id: 25778
Gene Symbol: DSTYK
DSTYK 		0.400 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 25778
Gene Symbol: DSTYK
DSTYK 		0.400 Biomarker disease HPO
Entrez Id: 7380
Gene Symbol: UPK3A
UPK3A 		0.250 AlteredExpression disease LHGDN Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux. 17880289 2007
Entrez Id: 7380
Gene Symbol: UPK3A
UPK3A 		0.250 AlteredExpression disease BEFREE Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux. 17880289 2007
Entrez Id: 7380
Gene Symbol: UPK3A
UPK3A 		0.250 Biomarker disease BEFREE Uroplakin IIIa (encoded by UPIIIA) is an integral membrane protein present in urothelial plaques, and the murine UPIIIa knockout is associated with urothelial anomalies and vesicoureteral reflux. 16731295 2006
Entrez Id: 7380
Gene Symbol: UPK3A
UPK3A 		0.250 Biomarker disease BEFREE Uroplakin III is not a major candidate gene for primary vesicoureteral reflux. 15523493 2005
Entrez Id: 7380
Gene Symbol: UPK3A
UPK3A 		0.250 GeneticVariation disease BEFREE No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux. 14713856 2004
Entrez Id: 7380
Gene Symbol: UPK3A
UPK3A 		0.250 Biomarker disease BEFREE Targeted disruption of angiotensin type II receptor and uroplakin III genes result in the phenotype of primary vesicoureteral reflux. 12640275 2003
Entrez Id: 7380
Gene Symbol: UPK3A
UPK3A 		0.250 Biomarker disease MGD Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. 11085999 2000
Entrez Id: 5076
Gene Symbol: PAX2
PAX2 		0.180 GeneticVariation disease BEFREE We reported a case of co-presence of LMX1B and PAX2 variants in a child with extrarenal manifestation of NPS and end-stage renal disease but congenital bilateral renal hypodysplasia and vesicoureteral reflux. 29973660 2018
Entrez Id: 5076
Gene Symbol: PAX2
PAX2 		0.180 AlteredExpression disease BEFREE The significance of Pax2 expression in the ureter epithelium of children with vesicoureteric reflux. 25912758 2015