|
KLRC4-KLRK1
|
0.100 |
Biomarker
|
group |
BEFREE |
They also mediate host injury by exerting cytotoxicity that is facilitated by natural killer cell-activating receptors, such as NKG2D, and cytolytic molecules, such as granzyme B. Interestingly, it has been recently reported that there is a strong association between the cytolytic function of bystander-activated CD8<sup>+</sup> T cells and host tissue injury in patients with acute hepatitis A virus infection.
|
31827070 |
2019 |
|
KLRC4-KLRK1
|
0.100 |
Biomarker
|
group |
BEFREE |
Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection.
|
29632146 |
2018 |
|
KLRC4-KLRK1
|
0.100 |
Biomarker
|
group |
BEFREE |
Research into the NKG2D mechanism of action has primarily been focused on cancer and viral infections where cytotoxicity evasion is a concern.
|
28926962 |
2017 |
|
KLRC4-KLRK1
|
0.100 |
Biomarker
|
group |
BEFREE |
This experimental approach may mimic the compromised function of NKG2D occurring in certain viral infections.
|
28603523 |
2017 |
|
KLRC4-KLRK1
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We now report that increased expression of NKG2D ligands after virus infection depends on interferon response factors activated by the detection of viral double-stranded RNA by pattern-recognition receptors (RIG-I/MDA-5) and that NKG2D ligand up-regulation can be blocked by the expression of viral dsRNA-binding proteins.
|
28986447 |
2017 |
|
KLRC4-KLRK1
|
0.100 |
Biomarker
|
group |
BEFREE |
NKG2D recognizes various MHC I-like ligands that are induced on target cells exposed to stressors such as viral infection, DNA damage and oncological transformation.
|
28414183 |
2017 |
|
KLRC4-KLRK1
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NKG2D is an activating receptor that can bind to a large number of stress-induced ligands that are expressed in the context of cancer or viral infection.
|
27667711 |
2016 |
|
KLRC4-KLRK1
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The NKG2D receptor confers important activating signals to NK cells via ligands expressed during cellular stress and viral infection.
|
23947399 |
2013 |
|
KLRC4-KLRK1
|
0.100 |
Biomarker
|
group |
BEFREE |
The recognition of ectopic surface-expressing endogenous antigen by TCRγδ and NKG2D may be an important mechanism of innate immune response to carcinogenesis and viral infection.
|
22433851 |
2012 |
|
KLRC4-KLRK1
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our data suggest that ULBP4 functions as a ligand for both TCRgammadelta and NKG2D and may play a key role in immune surveillance of tumor development and clearance of viral infection.
|
19436053 |
2009 |