Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE The clinical observation that AA can occur after viral infection or IFN-α administration implies that IFN-α-producing plasmacytoid dendritic cells (pDCs) may be involved in the AA pathogenesis. 31431342 2020
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE IFN responses to viral infection are necessary to establish intrinsic antiviral state, but if unchecked can lead to heightened inflammation. 31548332 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. 30995506 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection. 30195710 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE The interaction of FKBP8 with VISA, retinoic acid inducible protein 1 (RIG-I), and IFN regulatory factor 3 (IRF3) was confirmed during viral infection in mammalian cells by coimmunoprecipitation. 30267576 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Human UBL4A/GdX, encoding an ubiquitin-like protein, was shown in this study to be upregulated by viral infection and IFN stimulation. 31451677 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Using pharmacological and genetic approaches, we show that lactate reduction by lactate dehydrogenase A (LDHA) inactivation heightens type I IFN production to protect mice from viral infection. 31155231 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection. 31379819 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 AlteredExpression group BEFREE <b>Conclusions:</b> Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants and a subset of children. 30562046 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 AlteredExpression group BEFREE IFN α and β are two cytokines, which have a major activity in the innate immune system against viral infections. 30378208 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Overall, this research on CoBoIFN-ω not only extends and improves consensus IFN research, but also reveals that CoBoIFN-ω has the potential to be used in the therapy of bovine viral diseases. 30576951 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Commercially, IFN-α has been approved to treat many chronic viral diseases as well as a variety of cancers and different types of leukemia. 30543053 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE By extension, IFN-αβ or combination therapy may need to be used cautiously to treat viral infections in clinical settings. 31355779 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Type I interferon (IFN-I) is critical for antiviral defense, and plasmacytoid dendritic cells (pDCs) are a predominant source of IFN-I during virus infection. pDC-mediated antiviral responses are stimulated upon physical contact with infected cells, during which immunostimulatory viral RNA is transferred to pDCs, leading to IFN production via the nucleic acid sensor TLR7. 31003939 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters. 31784575 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Infectious bursal disease virus (IBDV) infection triggers the induction of type I IFN, which is mediated by melanoma differentiation-associated protein 5 recognition of the viral genomic double-stranded RNA (dsRNA). 29979632 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 AlteredExpression group BEFREE Among the 12 IFNα subtypes, IFNα1 has a uniquely low affinity for IFNAR2 (<100 × of the other IFNα subtypes) and commensurately weak antiviral activity, suggesting an undefined function distinct from suppression of viral infections. 30920934 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE IFN-stimulated gene expression establishes the antiviral state, limiting viral infection in IFN-α-stimulated microenvironments. 30282499 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 GeneticVariation group BEFREE Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP. 29990995 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 GeneticVariation group BEFREE A detailed immunological investigation of these patients revealed impaired responses to type I IFN, IL-10, IL-12 and IL-23, which are associated with increased susceptibility to mycobacterial and/or viral infections. 29725107 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses. 28963109 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE The contribution of distinct central nervous system (CNS) resident cells to protective alpha/beta interferon (IFN-α/β) function following viral infections is poorly understood. 29491163 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Polymorphisms in these genes may cause chronic dysregulated IFN signaling in islets, characterized by hyperexpression of IFN-I, the IFN gene signature, and major histocompatibility complex class I during viral infection. 29369915 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Type III IFN (IFN-λ) is the dominant frontline response over type I IFN in human normal intestinal epithelial cells upon viral infection, this response being mimicked by the dsRNA analog poly-IC. 30349642 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE Despite its beneficial effects in viral infections IFNα has been reported to be associated with several autoimmune diseases including autoimmune thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, primary biliary cholangitis, and recently emerged as a major cytokine that triggers Type 1 Diabetes. 30115527 2018