Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE Our findings provide the evidence that Rig-I is a key regulator of cellular senescence, which will be helpful in better understanding its function without viral infection.<b>Abbreviations:</b> Rig-I: retinoic acid inducible gene-I; SASP: senescence-associated secretory phenotype; ECM: extracellular matrix; Itgb3: integrin beta 3; PRR: pattern recognition receptor; MEFs: mouse embryonic fibroblasts; Il-1β: interleukin-1 beta; Il-6: interleukin-6; Il-8: interleukin-8; Cxcl1: chemokine (C-X-C motif) ligand 1; Ccl2: chemokine (C-C motif) ligand 2; WT, wild type; BM: bone marrow; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinases; JNK: Jun N-terminal kinases; SA-β-gal: senescence-associated β-galactosidase; qPCR: quantitative reverse-transcription PCR; PBS: phosphate-buffered saline. 31595820 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression group BEFREE The results show that the Ghs13 Leghorn subline had a consistently higher expression of all genes except IL-8 and expression seemed to be subline-dependent rather than breed-dependent, suggesting that the innate immune response of chicken embryos to NDV infection may be genetically controlled by the MHC-locus. 29535762 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE In the model of viral infection, production of IL-12 and interferon-gamma inducible protein (IP)-10 was reduced in both DC subsets, and IL-8 was reduced in BDCA3<sup>+</sup> DC following PC exposure. 28503991 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression group BEFREE Classical Swine Fever Virus Infection and Its NS4A Protein Expression Induce IL-8 Production through MAVS Signaling Pathway in Swine Umbilical Vein Endothelial Cells. 29375538 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE Taken together, the above results suggest that IL-36-mediated IL-6 and CXCL8 production in human lung fibroblasts and bronchial epithelial cells may be involved in pulmonary inflammation especially caused by bacterial or viral infections. 28869889 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE In this study, we found in vitro that expression of MVP, IL-6, and IL-8 was inducible upon dsRNA stimulation or viral infection. 26843330 2016
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression group BEFREE The pre-treatment of HeLa monolayer with inactivated bacterial cells 24 hours before the viral infection is increasing the expression level of TNF-a, IL-6 and IL-8 pro-inflammatory cytokines genes, also suggesting that bacterial antigens could contribute to the decrease of viral multiplication rate. 26193210 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression group BEFREE Viral infection (staining of F and G proteins, nucleoprotein RNA level), mRNA of ICAM-1, ciliated cell markers (digital high speed videomicroscopy, β-tubulin immunofluorescence, Foxj1 and Dnai2 mRNA), Goblet cells (PAS), mRNA of MUC5AC and CLCA1, mRNA and protein level of IL-13, IL-6, IL-8, TNFα, formation of H2O2 and the anti-oxidative armamentarium (mRNA of Nrf2, HO-1, GPx; total antioxidant capacity (TAC) were measured at day 10 or 15 post infection. 23936072 2013
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression group BEFREE We then examined cells with single or multiple virus infections for the expression of 10 cytokine genes and demonstrated elevated expressions for 7 (IFN-α, IFN-β, IFN-γ, TNF-α, IL-6, IL-8, and IL-17) in dual rotavirus and enterovirus or triple rotavirus, enterovirus and astrovirus-infected cells but only 3 (IFN-β, TNF-α, and IL-8) in dual rotavirus and astrovirus-infected cells. 22497974 2012
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE These results identify central roles for IL-1β and its signaling pathways in the production of CXCL8, a potent neutrophil chemoattractant, in viral infection. 21593174 2011
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 GeneticVariation group BEFREE Chromatin immunoprecipitation experiments indicated that binding of NFkappaB p65 and p50 subunits to the IL-8 promoter upon viral infection was differentially reduced by chemical inhibitors of MAPKs. 20038977 2009
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression group BEFREE Plasma levels of IL-1beta and IL-8 were elevated during measles virus infection. 17538120 2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE We investigated the roles of Toll-like receptor 2 (TLR2) and myeloid differentiation factor 88 (MyD88) in the course of a lymphocytic choriomeningitis virus (LCMV) infection and revealed the following: (i) studies of transfected cells and murine peritoneal macrophages demonstrated that TLR2 and MyD88 are essential for the initial pro-inflammatory cytokine response (human IL-8, mouse IL-6) to LCMV; (ii) TLR2 knockout (KO) mice and MyD88 KO mice challenged with LCMV produced less IL-6 and monocyte chemotactic protein-1 in the serum than wild-type mice; (iii) in contrast to inflammatory cytokines, the production of type 1 IFN (IFN-alpha) in response to LCMV was MyD88 independent; (iv) MyD88 plays an essential role in antiviral CD8(+) T cell responses, CD8(+) T cells in MyD88 KO mice were defective in their expression of intracellular antiviral cytokines; and (v) the failure of MyD88 KO mice to activate CD8(+) T cells was accompanied by persistent viral infection in MyD88 KO mice. 15724245 2005
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE Furthermore, expression of mRNA for inflammatory cytokines, release of infectious particles, and release of IL-6 and IL-8 were closely correlated with the degree of viral infection. 14711802 2004
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE To evaluate the biological effects of human herpesvirus-6 (HHV-6) infection, adult heart microvascular and aortic endothelial cells were examined for in vitro susceptibility to HHV-6 and for the alterations induced by viral infection on the production of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8). 12115999 2002
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE Interleukin-8 (IL8) is believed to play a role in the pathogenesis of bronchiolitis, a common viral disease of infancy, and a recent U.K. family study identified an association between this disease and the IL8-251A allele. 11431705 2001
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker group BEFREE Although CMV-infected astrocytes did not produce antiviral cytokines, they generated significant quantities of the chemokines MCP-1 and IL-8 in response to viral infection. 11517386 2001
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression group BEFREE This contrasts with Mopeia virus infection of HUVEC in which neither IL-8 mRNA nor protein are reduced. 10534741 1999
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression group BEFREE However, TNF, IL-1, and RSV, but not IL-6, induced IL-8 and IL-6 mRNA expression by the bronchial epithelial cells suggesting that cytokines produced by RSV-infected AM may be more important in modulating the inflammatory response in infection than directly interfering with virus infection/replication of airway epithelium. 1753101 1991