Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3454
Gene Symbol: IFNAR1
IFNAR1
0.340 Biomarker group BEFREE Viral infection induced metabolic alterations of the liver that depended on the interferon alpha/beta receptor (IFNAR1). 31784108 2019
Entrez Id: 3454
Gene Symbol: IFNAR1
IFNAR1
0.340 AlteredExpression group BEFREE In conclusion, down-regulation of CK1α during IBDV infection as a host defense response increased abundance of IFNAR1, which in turn enhanced an inhibitory effect on IBDV replication. 28988058 2017
Entrez Id: 3454
Gene Symbol: IFNAR1
IFNAR1
0.340 Biomarker group BEFREE Our findings illustrate an essential role for IRF9, as a mediator downstream of IFNAR, in preventing overwhelming antigen exposure causing CD8<sup>+</sup> T cell exhaustion and leading to chronic viral infection. 28878077 2017
Entrez Id: 3454
Gene Symbol: IFNAR1
IFNAR1
0.340 Biomarker group BEFREE Conditional IFNAR mice responded with a swift and strong CD8(+) T-cell response to viral infection, compared to a weak response in IFNAR(-/-) mice. 24741106 2014
Entrez Id: 3454
Gene Symbol: IFNAR1
IFNAR1
0.340 Biomarker group CTD_human Cigarette smoking condensate (but not pure nicotine) stimulated specific serine phosphorylation-dependent ubiquitination and degradation of the IFNAR1 subunit of the Type I IFN receptor leading to attenuation of IFN signaling and decreased resistance to viral infection. 18722370 2008
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
0.320 GeneticVariation group BEFREE The SS risk allele of rs10774671 has been shown by others to be associated with reduced OAS1 enzymatic activity and ability to clear viral infections, as well as reduced responsiveness to IFN treatment. 28640813 2017
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
0.320 Biomarker group BEFREE Although still preliminary, a few recent observations also substantiate a possible role for OAS1 in human susceptibility to viral infections (West Nile virus, SARS, etc.) and its possible involvement in some other diseases such as type 1 diabetes and multiple sclerosis. 18727488 2008
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
0.320 Biomarker group CTD_human This genetic polymorphism makes OAS1 an excellent candidate for a human gene that influences host susceptibility to viral infection. 15732009 2005
Entrez Id: 1051
Gene Symbol: CEBPB
CEBPB
0.250 AlteredExpression group BEFREE We hypothesize that dengue virus infection of the liver cells may trigger both an oxidant-dependent and an oxidant-independent pathway to up-regulate RANTES mRNA expression through activating NF-IL-6 and an undefined factor, respectively. 11022000 2000
Entrez Id: 1051
Gene Symbol: CEBPB
CEBPB
0.250 Biomarker group BEFREE Thus, NF-IL6 may play a significant role in the regulation of viral transcription as a part of the host's resistance to viral infection. 8380454 1993
Entrez Id: 1051
Gene Symbol: CEBPB
CEBPB
0.250 Biomarker group BEFREE Future studies will be required to clarify whether or not the interplay between NF-IL6 and viral infection is responsible for deregulation of the IL-6 gene. 1380488 1992
Entrez Id: 1051
Gene Symbol: CEBPB
CEBPB
0.250 AlteredExpression group BEFREE NF-IL6 is shown to recognize the enhancer core sequence of several viruses, suggesting a possible relationship of virus infection and IL-6 expression. 1380241 1992
Entrez Id: 1051
Gene Symbol: CEBPB
CEBPB
0.250 GeneticVariation group BEFREE Consistent with these functions, NF-IL6 alone is sufficient to complement an E1A deletion mutant dl312 in viral infection, when expressed at appropriate concentrations. 1309887 1992
Entrez Id: 1051
Gene Symbol: CEBPB
CEBPB
0.250 Biomarker group MGD
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.100 Biomarker group BEFREE Upon virus infection, LRRC59 specifically interacted with ISG15-associated DDX58 and blocked its association with LRRC25, the secondary receptor to deliver DDX58 to autophagosomes for SQSTM1/p62-dependent degradation, leading to the stronger antiviral immune responses. 31068071 2020
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.100 Biomarker group BEFREE Specifically, we demonstrate that DRH-1/RIG-I is required for inducing the IPR in response to Orsay virus infection, but not in response to other triggers like microsporidian infection or proteotoxic stress. 31619561 2020
Entrez Id: 5920
Gene Symbol: PLAAT4
PLAAT4
0.100 Biomarker group BEFREE Specifically, we demonstrate that DRH-1/RIG-I is required for inducing the IPR in response to Orsay virus infection, but not in response to other triggers like microsporidian infection or proteotoxic stress. 31619561 2020
Entrez Id: 64221
Gene Symbol: ROBO3
ROBO3
0.100 Biomarker group BEFREE Specifically, we demonstrate that DRH-1/RIG-I is required for inducing the IPR in response to Orsay virus infection, but not in response to other triggers like microsporidian infection or proteotoxic stress. 31619561 2020
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE Meanwhile, NLRP3 inflammasome can suppress FMDV replication during virus infection. 31840571 2020
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker group BEFREE These findings suggest that treatment with the TLR4 agonist Immunomax polarizes the immune response towards antiviral Th1 and may be used for short-term antiviral prophylaxis to prevent acute respiratory viral infections in asthmatics. 30713767 2020
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker group BEFREE The mitochondrial transcription factor A (TFAM), plays a vital role in mitochondrial DNA (mtDNA) metabolism and has been suggested to influence IFN-β production in response to viral infection. 31495880 2020
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 GeneticVariation group BEFREE Efficient engagement with the envelope glycoprotein membrane-proximal external region (MPER) results in robust blocking of viral infection by a class of broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV). 31787208 2020
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker group BEFREE The clinical observation that AA can occur after viral infection or IFN-α administration implies that IFN-α-producing plasmacytoid dendritic cells (pDCs) may be involved in the AA pathogenesis. 31431342 2020
Entrez Id: 3661
Gene Symbol: IRF3
IRF3
0.100 AlteredExpression group BEFREE Being induced by viral infection is a defining characteristic of interferons, but viral infection or overexpression of members of the interferon regulatory factor (IRF) family of transcription factors only leads to a minute induction of <i>IFNL4</i> This behavior is evolutionarily conserved and can be reversed by inserting a functional IRF3 binding site into the <i>IFNL4</i> promoter. 31776283 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression group BEFREE Here, we found that H3K79me2/3 modification levels at the Il6 and Ifnb1 promoters, as well as H3K79me2 modification at the Tnfα promoter, were increased in macrophages activated by Toll-like receptor (TLR) ligands or virus infection. 30275539 2020