Gene: MAPK3 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3 		0.020 Biomarker phenotype BEFREE Furthermore, our behavioral findings demonstrated that the following agents suppressed vomiting evoked by GR73632 in a dose-dependent manner: i) the NK<sub>1</sub>R antagonist netupitant (i.p.); ii) the L-type Ca<sup>2+</sup> channel (LTCC) antagonist nifedipine (subcutaneous, s.c.); iii) the inositol trisphosphate receptor (IP<sub>3</sub>R) antagonist 2-APB (i.p.); iv) store-operated Ca<sup>2+</sup> entry inhibitors YM-58483 and MRS-1845, (i.p.); v) the ERK1/2 pathway inhibitor U0126 (i.p.); vi) the PKC inhibitor GF109203X (i.p.); and vii) the inhibitor of phosphatidylinositol 3-kinase (PI3K)-Akt pathway LY294002 (i.p.). 30453005 2019
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3 		0.020 AlteredExpression phenotype BEFREE Our results indicate associations between cisplatin's peak immediate- and delayed-phase vomiting frequency with increased: (1) expression levels of NK(1) receptor mRNA and its protein level, and (2) downstream NK(1) receptor-mediated phosphorylation of ERK1/2 and PKA signaling. 23001014 2013