| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | disease | BEFREE | We crossed p53 mutant mice (p53N236S, p53S) with Werner syndrome mice and analyzed the pathological phenotypes. | 31119048 | 2019 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Erythroblasts negative for WRN immunostaining were only observed in two patients, both of whom were diagnosed with WS: one with concomitant myelodysplastic syndrome and the other with erythroleukemia with overexpression of TP53. | 25503078 | 2015 | ||||
|
0.090 | Biomarker | disease | BEFREE | The Werner syndrome helicase (WRN) participates in DNA replication, double strand break repair, telomere maintenance, and p53 activation. | 17317667 | 2007 | ||||
|
0.090 | Biomarker | disease | BEFREE | The conclusions from these studies are that: (1) replicative senescence in Werner-syndrome fibroblasts is a telomere-induced p53-dependent event; and (2) the intermediate lifespan barrier M(int) is also a telomere-induced event, although it appears to be independent of p53. | 12615976 | 2003 | ||||
|
0.090 | Biomarker | disease | BEFREE | The regulation of WRN function by p53 is likely to play an important role in the maintenance of genomic integrity and prevention of cancer and other clinical symptoms associated with WS. | 11427532 | 2001 | ||||
|
0.090 | Biomarker | disease | BEFREE | Furthermore, the failure to induce p53 effectively may contribute to enhanced genomic instability and elevated cancer risk in WS patients. | 11023999 | 2000 | ||||
|
0.090 | Biomarker | disease | BEFREE | Physical and functional interaction between p53 and the Werner's syndrome protein. | 10506209 | 1999 | ||||
|
0.090 | Biomarker | disease | BEFREE | These data support the hypothesis that p53 can induce apoptosis through the modulation of specific DExH-containing DNA helicases and may have implications for the cancer predisposition observed in WS patients. | 10364153 | 1999 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | The levels of p53 were not increased in senescent fibroblasts, whether derived from normal or WS subjects. | 7822435 | 1995 |