Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6469
Gene Symbol: SHH
SHH
0.300 Biomarker disease CTD_human Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model. 27585885 2016
Entrez Id: 2736
Gene Symbol: GLI2
GLI2
0.300 Biomarker disease CTD_human Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model. 27585885 2016
Entrez Id: 4838
Gene Symbol: NODAL
NODAL
0.300 Biomarker disease CTD_human NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos. 23264560 2013
Entrez Id: 6469
Gene Symbol: SHH
SHH
0.300 Biomarker disease CTD_human NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos. 23264560 2013
Entrez Id: 2619
Gene Symbol: GAS1
GAS1
0.300 Biomarker disease CTD_human Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog. 17525797 2007
Entrez Id: 6469
Gene Symbol: SHH
SHH
0.300 Biomarker disease CTD_human Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog. 17525797 2007
Entrez Id: 7050
Gene Symbol: TGIF1
TGIF1
0.300 Biomarker disease CTD_human Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling. 16705179 2006
Entrez Id: 6469
Gene Symbol: SHH
SHH
0.300 Biomarker disease CTD_human Wide phenotypic variability in families with holoprosencephaly and a sonic hedgehog mutation. 15107988 2004
Entrez Id: 57045
Gene Symbol: TWSG1
TWSG1
0.300 Biomarker disease CTD_human The mammalian twisted gastrulation gene functions in foregut and craniofacial development. 15013800 2004
Entrez Id: 6997
Gene Symbol: TDGF1
TDGF1
0.300 Biomarker disease CTD_human A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects. 12073012 2002
Entrez Id: 6496
Gene Symbol: SIX3
SIX3
0.300 Biomarker disease CTD_human Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly. 10369266 1999
Entrez Id: 2737
Gene Symbol: GLI3
GLI3
0.110 GeneticVariation disease BEFREE Meanwhile, it was speculated that the Gli3 gene, mutation of which is responsible for the arhinencephaly in Pdn/Pdn mice, might play a role in mesenchymal programmed cell death during development. 8711131 1995
Entrez Id: 2737
Gene Symbol: GLI3
GLI3
0.110 Biomarker disease HPO
Entrez Id: 10535
Gene Symbol: RNASEH2A
RNASEH2A
0.100 Biomarker disease HPO
Entrez Id: 9632
Gene Symbol: SEC24C
SEC24C
0.100 Biomarker disease HPO
Entrez Id: 64093
Gene Symbol: SMOC1
SMOC1
0.100 Biomarker disease HPO
Entrez Id: 79621
Gene Symbol: RNASEH2B
RNASEH2B
0.100 Biomarker disease HPO
Entrez Id: 11277
Gene Symbol: TREX1
TREX1
0.100 Biomarker disease HPO
Entrez Id: 6239
Gene Symbol: RREB1
RREB1
0.100 Biomarker disease HPO
Entrez Id: 374654
Gene Symbol: KIF7
KIF7
0.100 Biomarker disease HPO
Entrez Id: 219844
Gene Symbol: HYLS1
HYLS1
0.100 Biomarker disease HPO
Entrez Id: 7353
Gene Symbol: UFD1
UFD1
0.100 Biomarker disease HPO
Entrez Id: 84153
Gene Symbol: RNASEH2C
RNASEH2C
0.100 Biomarker disease HPO
Entrez Id: 103
Gene Symbol: ADAR
ADAR
0.100 Biomarker disease HPO
Entrez Id: 2187
Gene Symbol: FANCB
FANCB
0.100 Biomarker disease HPO