Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE Degradation of PRC2 with UNC6852 blocks the histone methyltransferase activity of EZH2, decreasing H3K27me3 levels in HeLa cells and diffuse large B cell lymphoma (DLBCL) cells containing EZH2 gain-of-function mutations. 31831267 2020
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 Biomarker disease BEFREE In this study, we treated Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) cell lines with 3-deazaneplanocin-A (DZNep), an indirect EZH2 inhibitor which possesses anticancer properties both in-vitro and in-vivo. 31419226 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE Germinal center-like DLBCL is enriched for activating EZH2 mutations, and encouraging activity has been observed for the EZH2 inhibitor tazemetostat, which now has a fast-track US Food and Drug Administration designation. 31287161 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE EZH2 inhibitors reversed the upregulation of trimethylation of H3K27, and synergistically inhibited diffuse large B-cell lymphoma and other solid tumors growth in vitro and in vivo. 31289198 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE Univariate analyses revealed that EZH2/Bcl-2 coexpression correlated to worse objective response rate (ORR), shorter OS and PFS in DLBCL patients treated with RCHOP while multivariate analysis indicated that only elevated LDH level (<i>P</i>=0.001) and presence of B symtom (<i>P</i>=0.008) rather than EZH2/Bcl-2 coexpression were associated with worse OS. 31205561 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE Of clinical relevance, EZH2 inhibitors significantly restored MHC expression in <i>EZH2</i>-mutated human DLBCL cell lines. 30705065 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE We also identified multiple acquired mutations in EZH2 inhibitor-resistant DLBCL cell lines. 29572378 2018
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE Tazemetostat, first-in-class EZH2 inhibitor, demonstrated enhanced clinical activity in mutant follicular lymphoma and diffuse large B cell lymphoma. 30112706 2018
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 Biomarker disease BEFREE EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL. 28835384 2017
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features. 28438623 2017
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE We investigated RUNX3 and EZH2 expression in diffuse large B-cell lymphoma (DLBCL). 27184221 2017
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 Biomarker disease BEFREE Moreover, oncogenic BCL6 and EZH2 cooperate to accelerate diffuse large B cell lymphoma (DLBCL) development and combinatorial targeting of these repressors results in enhanced anti-lymphoma activity in DLBCLs. 27505670 2016
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 Biomarker disease BEFREE We investigated the potential signaling molecules that regulate EZH2 overexpression in aggressive B-cell lymphomas and found that 80% of cases of EZH2-positive diffuse large B-cell lymphoma show high p-ERK1/2 expression (average ~57% tumor cell positivity). 27282353 2016
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE Prioritized alterations in epigenetic modulators were common and included gain-of-function EZH2 and loss-of-function ARID1A mutations (14% of diffuse large B-cell lymphomas and 22% of follicular lymphomas contained alterations in each of these two genes). 27102345 2016
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma. 25605023 2015
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE High-level EZH2 and H3K27me3 were common in DLBCL independent of cell-of-origin and EZH2 mutation. 25651430 2015
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE Here, we discuss the function of histone acetyltransferases (CREBBP, EP300), histone methyltransferases (KDM2C/D, EZH2) and regulators of higher order chromatin structure (HIST1H1C/D/E, ARID1A and SMARCA4) that have been reported to be mutated in ⩾5% of DLBCL, FL or BL. 26473533 2015
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE Recurrent somatic heterozygous gain-of-function mutations of EZH2 have been identified in DLBCL, most notably affecting tyrosine 641 (Y641), inducing hyper-trimethylation of H3K27 (H3K27me3). 25762637 2015
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE In particular, recurrent gain-of-function mutations targeting EZH2 Y641 occur most frequently in follicular lymphoma and aggressive diffuse large B-cell lymphoma and are associated with H3K27me3 hyperactivation, which contributes to lymphoma pathogenesis. 24469040 2015
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 Biomarker disease BEFREE Activating mutations of genes involved in the BCR and NF-κB pathways (CD79A, CD79B, MYD88, and CARD11) or in epigenetic regulation (EZH2) have been recently reported, preferentially in one of the two DLBCL subtypes. 24327543 2014
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE The histone methyltransferase EZH2 is frequently mutated in germinal center-derived diffuse large B-cell lymphoma and follicular lymphoma. 24802772 2014
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 Biomarker disease BEFREE In conclusion, H3K27me3 was related to EZH2 and c-Myc expression, suggesting formation of a MYC-EZH2-H3K27me3 loop in a subgroup of DLBCL cases. 25149548 2014
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 AlteredExpression disease BEFREE We demonstrated that DLBCL was associated with increased expression of the EZH2 PcG protein and Ki67. 24304372 2014
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 GeneticVariation disease BEFREE Gain-of-function mutations of enhancer of Zeste homolog 2 (EZH2) occur frequently in diffuse large B-cell lymphomas and in follicular lymphomas. 24634383 2014
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.700 Biomarker disease BEFREE Mutations in EZH2 (Y646) and CD79B (Y196) were detected in 13.2% and 8% of the samples, respectively, almost exclusively in follicular lymphomas and diffuse large B-cell lymphomas. 23361872 2013