Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 AlteredExpression disease BEFREE In this study, we analyzed the prevalence of 9p24.1 CNA in newly diagnosed DLBCL and examined its association with PD-L1, PD-L2, and JAK2 expression, clinical characteristics, and outcome. 31471540 2019
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 Biomarker disease BEFREE We found that PD-L1 expression, particularly in nongerminal center B cell-derived diffuse large B-cell lymphoma (DLBCL), is controlled and regulated by several interactive signaling pathways, including the B-cell receptor (BCR) and JAK2/STAT3 signaling pathways. 30209121 2018
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 Biomarker disease BEFREE The place of JAK2 inhibitors in the treatment of diffuse large B-cell lymphoma has not been defined; we suggest that JAK2 inhibitors might be most effective in poor prognosis ABC-DLBCL, which shows higher levels of IL10RA, JAK2, and STAT3 but lower levels of BCL6 than GC-DLBCL and might be usefully combined with novel approaches such as inhibition of IL10RA. 27268052 2016
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 AlteredExpression disease BEFREE HDAC inhibition abolished STAT3(Tyr705) phosphorylation with minimal effect on STAT3(Ser727) and JAK2 tyrosine activity. pSTAT3(Tyr705)-positive DLBCLs were more sensitive to HDAC inhibition with LBH589 compared with pSTAT3(Tyr705)-negative DLBCLs. 22116549 2012
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 Biomarker disease BEFREE Two patients with diffuse large B cell lymphoma displayed complex karyotype and JAK2 amplification by FISH. 20331734 2010
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 Biomarker disease BEFREE Recently, our work comparing gene expression signatures of primary mediastinal large B-cell lymphomas (PMLBCL) versus nodal diffuse large B-cell lymphomas revealed a relative increase in JAK2 transcripts in the former, suggesting a role for increased JAK2 signaling in a subset of these tumors. 19704259 2009
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 GeneticVariation disease BEFREE Fluorescence in situ hybridization analysis did not reveal involvement of the JAK2 gene, located at chromosome band 9p24, and previously shown to be amplified in Hodgkin lymphoma and primary mediastinal diffuse large B-cell lymphoma. 17460466 2007
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 AlteredExpression disease BEFREE We demonstrated an amplification of the JAK2 gene in 2 of 6 PMBL cases, and showed higher JAK2 mRNA levels in PMBL compared with DLBCL (P =.005). 15044251 2004
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.380 GenomicAlterations disease CGI