Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.010 Biomarker disease BEFREE The aim of this study was to explore the diagnostic value of pleural fluid angiotensin-converting enzyme (ACE), calpain-1, spectrin breakdown products (SBDP), and matrix metalloproteinase-1 (MMP-1) in TPE and malignant pleural effusion (MPE). 29997916 2018
Entrez Id: 100
Gene Symbol: ADA
ADA
0.050 Biomarker disease BEFREE Increased Cytokeratin 19 Fragment Levels Are Positively Correlated with Adenosine Deaminase Activity in Malignant Pleural Effusions from Adenocarcinomas. 29854023 2018
Entrez Id: 100
Gene Symbol: ADA
ADA
0.050 Biomarker disease BEFREE Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion. 27976800 2017
Entrez Id: 100
Gene Symbol: ADA
ADA
0.050 Biomarker disease BEFREE CEA, NGAL, ADA and IFNy were useful in discriminating ME and TPE. 31310745 2019
Entrez Id: 100
Gene Symbol: ADA
ADA
0.050 Biomarker disease BEFREE Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion. 31709646 2020
Entrez Id: 100
Gene Symbol: ADA
ADA
0.050 Biomarker disease LHGDN Differential diagnosis of tuberculous and malignant pleural effusions: what is the role of adenosine deaminase? 18357489 2008
Entrez Id: 238
Gene Symbol: ALK
ALK
0.040 Biomarker disease BEFREE Malignant pleural effusion cell block samples had a diagnostic performance for ALK detection in advanced NSCLC that was comparable to that of tumour tissue samples. 25257756 2015
Entrez Id: 238
Gene Symbol: ALK
ALK
0.040 Biomarker disease BEFREE EML4-ALK rearrangement detection in malignant pleural effusions is a complementary method for EML4-ALK detection. 27060609 2016
Entrez Id: 238
Gene Symbol: ALK
ALK
0.040 Biomarker disease BEFREE We present a case of a 50-year-old man with a diagnosis of ALK-rearranged NSCLC with brain metastasis and malignant pleural effusion. 24022905 2013
Entrez Id: 238
Gene Symbol: ALK
ALK
0.040 GeneticVariation disease BEFREE Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis. 27352172 2016
Entrez Id: 250
Gene Symbol: ALPP
ALPP
0.010 Biomarker disease BEFREE The objective of our study was to analyze the prognostic value of the combination of serum ALP and pleural effusion LDH (AL score) for malignant pleural effusion (MPE) patients. 31837116 2020
Entrez Id: 324
Gene Symbol: APC
APC
0.010 Biomarker disease BEFREE Methylation of one of three genes (P16, E-cadherin, APC) was found in 14 out of 31 (45.2%) cases of malignant effusion, and in two out of 39 (5.1%) cases of non-malignant effusion (p = 0.000004). 18055295 2007
Entrez Id: 348
Gene Symbol: APOE
APOE
0.010 Biomarker disease BEFREE Many human lung cancer cell lines express apolipoprotein E (ApoE), especially cells derived from malignant pleural effusions (MPE) in patients with lung adenocarcinoma. 20430468 2011
Entrez Id: 374
Gene Symbol: AREG
AREG
0.010 Biomarker disease BEFREE The amphiregulin concentration was high in the supernatant fluid from five patients with malignant pleural effusion (116.4-18934.0 pg/ml). 23344087 2013
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.010 Biomarker disease BEFREE The objective of our study was to analyze the prognostic value of the combination of serum ALP and pleural effusion LDH (AL score) for malignant pleural effusion (MPE) patients. 31837116 2020
Entrez Id: 470
Gene Symbol: ATHS
ATHS
0.010 Biomarker disease BEFREE The objective of our study was to analyze the prognostic value of the combination of serum ALP and pleural effusion LDH (AL score) for malignant pleural effusion (MPE) patients. 31837116 2020
Entrez Id: 26033
Gene Symbol: ATRNL1
ATRNL1
0.010 Biomarker disease BEFREE The objective of our study was to analyze the prognostic value of the combination of serum ALP and pleural effusion LDH (AL score) for malignant pleural effusion (MPE) patients. 31837116 2020
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.010 Biomarker disease BEFREE On the other hand, positive BAP1 nuclear staining can occur in both benign and malignant pleural effusions. 30520251 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.010 Biomarker disease BEFREE Establishment of a human herpes virus-8-negative malignant effusion lymphoma cell line (STR-428) carrying concurrent translocations of BCL2 and c-MYC genes. 17368758 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.010 GeneticVariation disease BEFREE Cells grown from malignant pleural effusion were sensitive to BRAF V600E inhibitor and were more vulnerable to a combination treatment with osimertinib. 27923714 2017
Entrez Id: 823
Gene Symbol: CAPN1
CAPN1
0.010 Biomarker disease BEFREE The aim of this study was to explore the diagnostic value of pleural fluid angiotensin-converting enzyme (ACE), calpain-1, spectrin breakdown products (SBDP), and matrix metalloproteinase-1 (MMP-1) in TPE and malignant pleural effusion (MPE). 29997916 2018
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6
0.010 Biomarker disease BEFREE Multiplex reverse transcription-polymerase chain reaction (RT-PCR) was used to detect KIF5B-RET and CCDC6-RET fusions from specimens of malignant pleural effusion (MPE) in patients with metastatic lung adenocarcinoma. 25773866 2015
Entrez Id: 6356
Gene Symbol: CCL11
CCL11
0.010 Biomarker disease LHGDN The local cytokine and chemokine milieu within malignant effusions. 18515987 2008
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.010 Biomarker disease LHGDN The local cytokine and chemokine milieu within malignant effusions. 18515987 2008
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.020 AlteredExpression disease BEFREE We found that CCL22 level in MPE was significantly higher than that in non-malignant pleural effusion. 30928379 2019