Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1084
Gene Symbol: CEACAM3
CEACAM3
0.010 Biomarker disease BEFREE For malignant effusion (ME) diagnosis, CEA and NGAL presented superior performance than VEGF-A, PD-L1 and CALP. 31310745 2019
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.010 Biomarker disease BEFREE For malignant effusion (ME) diagnosis, CEA and NGAL presented superior performance than VEGF-A, PD-L1 and CALP. 31310745 2019
Entrez Id: 3934
Gene Symbol: LCN2
LCN2
0.010 Biomarker disease BEFREE For malignant effusion (ME) diagnosis, CEA and NGAL presented superior performance than VEGF-A, PD-L1 and CALP. 31310745 2019
Entrez Id: 2346
Gene Symbol: FOLH1
FOLH1
0.010 Biomarker disease BEFREE 68Ga-Prostate-Specific Membrane Antigen Uptake in a Malignant Pleural Effusion From Metastatic Prostate Cancer After Pleurodesis. 31283614 2019
Entrez Id: 10631
Gene Symbol: POSTN
POSTN
0.010 Biomarker disease BEFREE Identification and diagnostic value of pleural fluid periostin and serum periostin of malignant pleural effusions in patients with non-small-cell lung cancer. 31268191 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.010 Biomarker disease BEFREE The concentrations of IL-33 (mean ± SD) in tuberculous pleural effusion (TPE) group (22.5 ± 0.90 ng/l) were significantly higher than that of malignant pleural effusion (MPE) group (14.6 ± 2.35 ng/l; P <  0.001). 31238901 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Ratio of carcinoembryonic antigen in pleural fluid and serum for the diagnosis of malignant pleural effusion. 31205509 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation disease BEFREE In particular, we assessed the efficacy of osimertinib for NSCLC with EGFR T790 M mutations in patients who were diagnosed with EGFR T790 M mutation by malignant effusion. 31183631 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.060 GeneticVariation disease BEFREE In the present study, PANAMutyper™ and PNAClamp™ were compared for the detection of KRAS mutations using different samples of patients with malignant pleural effusion. 31028221 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE The levels of HF-BF#, HF-BF%, and CEA in the malignant effusion group were significantly higher than those in the benign control group. 31018036 2019
Entrez Id: 7083
Gene Symbol: TK1
TK1
0.010 Biomarker disease BEFREE Thymidine kinase 1 concentration in pleural effusion is a diagnostic marker and survival predictor for malignant pleural effusion. 30985967 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.030 Biomarker disease BEFREE Macrophage-derived CCL22 promotes an immunosuppressive tumor microenvironment via IL-8 in malignant pleural effusion. 30928379 2019
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.020 AlteredExpression disease BEFREE We found that CCL22 level in MPE was significantly higher than that in non-malignant pleural effusion. 30928379 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation disease BEFREE It was also better at identifying lung cancer patients with malignant pleural effusion who were likely to benefit from EGFR-TKI treatment. 30804147 2019
Entrez Id: 256646
Gene Symbol: NUTM1
NUTM1
0.010 AlteredExpression disease BEFREE Midline carcinoma expressing NUT in malignant effusion cytology. 30734527 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.010 Biomarker disease BEFREE IL-10 promotes malignant pleural effusion in mice by regulating T<sub>H</sub> 1- and T<sub>H</sub> 17-cell differentiation and migration. 30695099 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.060 Biomarker disease BEFREE We retrospectively assessed outcomes in patients with malignant pleural effusion (MPE) who had previously received radiotherapy for non-small-cell lung cancer (NSCLC) within 18 months before the intrapleural infusion of IL-2 or cisplatin. 30619280 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.020 Biomarker disease BEFREE IL-17A-Producing γδT Cells Inhibit the Formation of Malignant Pleural Effusions. 30608868 2019
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
0.020 GeneticVariation disease BEFREE Detecting EGFR mutations and ALK/ROS1 rearrangements in non-small cell lung cancer using malignant pleural effusion samples. 30565433 2019
Entrez Id: 3326
Gene Symbol: HSP90AB1
HSP90AB1
0.010 Biomarker disease BEFREE The intention of this research was to test the level of Hsp90-beta in malignant pleural effusion (MPE) of patients with lung cancer and disclose the clinical significance of Hsp90-beta as a potential tumor marker for differential diagnosis of pleural effusion caused by lung cancer. 30522463 2018
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.010 Biomarker disease BEFREE On the other hand, positive BAP1 nuclear staining can occur in both benign and malignant pleural effusions. 30520251 2019
Entrez Id: 1116
Gene Symbol: CHI3L1
CHI3L1
0.010 Biomarker disease BEFREE Hence, we conducted this study to evaluate the utility of pleural fluid YKL-40 to detect malignant pleural effusion. 30471784 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Diagnostic benefits of the combined use of liquid-based cytology, cell block, and carcinoembryonic antigen immunocytochemistry in malignant pleural effusion. 30233867 2018
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
0.020 GeneticVariation disease BEFREE We first identified and reported interstitial lung disease induced de novo by crizotinib in a 47-year-old female patient who was diagnosed with advanced lung adenocarcinoma with a ROS1 rearrangement in a malignant pleural effusion. 30029601 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE In lung adenocarcinoma, CEA elevation can be found in both serum and malignant pleural effusion. 29997989 2018