Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease BEFREE The report highlights that the inframe deletion in MTRR exon 1 could be a high risk factor susceptibility to spina bifida. 28712006 2017
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease BEFREE With respect to spina bifida, we observed ORs with 95% confidence intervals that did not include 1.0 for the following SNPs (heterozygous or homozygous) relative to the reference genotype: BHMT (rs3733890) OR = 1.8 (1.1-3.1), CBS (rs2851391) OR = 2.0 (1.2-3.1); CBS (rs234713) OR = 2.9 (1.3-6.7); MTHFD1 (rs2236224) OR = 1.7 (1.1-2.7); MTHFD1 (hcv11462908) OR = 0.2 (0-0.9); MTHFD2 (rs702465) OR = 0.6 (0.4-0.9); MTHFD2 (rs7571842) OR = 0.6 (0.4-0.9); MTHFR (rs1801133) OR = 2.0 (1.2-3.1); MTRR (rs162036) OR = 3.0 (1.5-5.9); MTRR (rs10380) OR = 3.4 (1.6-7.1); MTRR (rs1801394) OR = 0.7 (0.5-0.9); MTRR (rs9332) OR = 2.7 (1.3-5.3); TYMS (rs2847149) OR = 2.2 (1.4-3.5); TYMS (rs1001761) OR = 2.4 (1.5-3.8); and TYMS (rs502396) OR = 2.1 (1.3-3.3). 19493349 2009
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease LHGDN The MTRR 66GG genotype increased maternal spina bifida risk by 2.1-fold (OR 2.1, 95% CI 1.3-3.3). 17024475 2006
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease BEFREE The MTRR 66GG genotype increased maternal spina bifida risk by 2.1-fold (OR 2.1, 95% CI 1.3-3.3). 17024475 2006
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease LHGDN Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida. 12590188 2003
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease BEFREE Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida. 12590188 2003
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 Biomarker disease BEFREE The purpose of this study is to investigate whether gene polymorphisms of methionine synthase (MTR) and methionine synthase reductase (MTRR) are involved in the risk for NTDs, specifically spina bifida. 12649067 2003
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease LHGDN For both variants, the risk of having a child with spina bifida appears to increase with the number of high-risk alleles in the maternal genotype: MTR (R1=2.16, 95% CI 0.92-5.06; R2=6.58, 95% CI 0.87-49.67) and MTRR (R1=2.05, 95% CI 1.05-3.99; R2=3.15, 95% CI 0.92-10.85). 12375236 2002
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease BEFREE Some data suggest that the risk for spina bifida associated with C677T homozygosity may depend on nutritional status (e.g., blood folate levels, intake of vitamins) or on the genotype of other folate-related genes (e.g., cystathionine-beta-synthase and methionine synthase reductase). 10791559 2000
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 GeneticVariation disease BEFREE A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. 10444342 1999
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.180 Biomarker disease HPO