Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression group BEFREE Medulloblastomas, the most frequent embryonal CNS tumors, are divided into four molecularly defined groups according to the WHO 2016 Classification: wingless/integrated (WNT) signaling pathway activated, sonic hedgehog (SHH) signaling pathway activated and tumor protein p53 gene (TP53)-mutant, SHH-activated and TP53-wildtype, and non-WNT/non-SHH-activated. 31124566 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group GWASCAT Genome-wide association study identifies multiple susceptibility loci for glioma. 26424050 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, and other early-onset tumors. 22691290 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE We previously reported an unusual accumulation of CNS tumors associated with a unique p53 germline mutation, Y236delta (deletion of codon 236). 11103934 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE Given the high accuracy and sensitivity of the yeast assay and previous negative results using conventional techniques, this indicates that p53 mutation is a rare event in non-astrocytic CNS tumor types examined here. 9542595 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE It remains to be shown whether this unusual pattern of CNS tumors is due to an organ-specific effect of this particular p53 mutation or whether it reflects the genetic background of the affected families. 9825943 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE Our results not only confirm the low penetrance of the TP53 gene on pediatric CNS tumors, but also provide further evidence of a putative tumor suppressor gene distal to TP53, between markers (D17S938, D17S926) and 17pter, specifically taking part in the development of PNET. 9546059 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression group BEFREE There was no relationship between bcl-2 expression and p53 gene status: approximately equal numbers of tumors with either wild-type or mutant p53 were bcl-2 negative or bcl-2 positive. bcl-2 expression is high (40-100%) among other tumors of the central nervous system which also show low malignant potential. 9341939 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression group BEFREE Alterations of the p53 protein, which is a 53 kD phosphoprotein and gene product of the p53 gene, has been found to play a major role in the genesis of a variety of human malignancies including tumors of the central nervous system. 9225141 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE The p53 tumor suppressor gene is frequently mutated in human cancer, and is important in the pathogenesis of other central nervous system (CNS) tumors. 8699232 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation group BEFREE The observation that somatic p53 mutations in sporadic brain tumours are largely restricted to those of astrocytic origin and that astrocytomas also prevail among CNS neoplasms associated with p53 germline mutation strongly suggests, that p53 mutations are capable of initiating neoplastic transformation in astrocytes of the human nervous system. 7582239 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression group BEFREE Our results indicate that p53 protein is expressed in a number of central nervous system neoplasms, and suggest that in astrocytic tumors a possible association may exist between p53 protein expression and tumor progression through increasing histological grades of malignancy. 8337939 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker group BEFREE This study points to the possible role of the p53 tumor suppressor gene in some central nervous system neoplasms of divergent histogenesis. 1933879 1991
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.310 GeneticVariation group BEFREE Notably, tumors demonstrating chromosome 3 monosomy and BAP1 alterations formed a homogeneous subset within this group.<b>Conclusions:</b> Integrated molecular profiling aids in distinguishing primary from metastatic melanocytic tumors of the central nervous system. 29891723 2018
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.310 Biomarker group CTD_human Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area. 25231345 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.310 GeneticVariation group BEFREE Genotype-phenotype correlations between APC gene mutations and central nervous system (CNS) tumors have, thus far not been successful. 17238184 2007
Entrez Id: 324
Gene Symbol: APC
APC
0.310 CausalMutation group CGI
Entrez Id: 324
Gene Symbol: APC
APC
0.310 GenomicAlterations group CGI
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.300 CausalMutation group CGI
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.300 GenomicAlterations group CGI
Entrez Id: 6598
Gene Symbol: SMARCB1
SMARCB1
0.190 Biomarker group BEFREE Secondary INI1-deficient rhabdoid tumors of the central nervous system: analysis of four cases and literature review. 31707588 2019
Entrez Id: 6598
Gene Symbol: SMARCB1
SMARCB1
0.190 AlteredExpression group BEFREE The loss of INI1 protein activity was first demonstrated in aggressive pediatric tumors, including atypical teratoid/rhabdoid (AT/RT) tumor of the central nervous system and malignant rhabdoid tumor of the kidney. 30856630 2019
Entrez Id: 6598
Gene Symbol: SMARCB1
SMARCB1
0.190 Biomarker group BEFREE CNS and extra-CNS tumors had an identical SMARCB1 amplification (n = 1) or very similar DNA methylation pattern (n = 1) suggestive of clonal origin.All patients died of tumor progression. 29428974 2018