Since almost 50% of cases are negative rare ovary-related CNVs, array-CGH together with next generation sequencing might represent the most suitable approach to obtain a comprehensive genetic characterization of POI patients.
Therefore, we performed array-CGH analysis by using high-resolution Agilent oligonucleotide arrays in a total of 74 POF and OD patients and identified 44 private losses and gains potentially causative for POF.