×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
CausalMutation
disease
CLINVAR
Rare, protein-truncating variants in ATM , CHEK2 and PALB2 , but not XRCC2 , are associated with increased breast cancer risks.
28779002
2017
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
CausalMutation
disease
CLINVAR
Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers.
27751358
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
GeneticVariation
disease
CLINVAR
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
22419737
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
CausalMutation
disease
CLINVAR
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
22419737
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
CausalMutation
disease
CLINVAR
The contribution of CHEK2 to the TP53-negative Li-Fraumeni phenotype.
19338683
2009
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
CausalMutation
disease
CLINVAR
Germline CHEK2*1100delC mutations in breast cancer patients with multiple primary cancers.
15520402
2004
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
GeneticVariation
disease
CLINVAR
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
12049740
2002
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
CausalMutation
disease
CLINVAR
Our observations support the functional significance of CHK2 mutations in rare cases of LFS and suggest that such mutations may substitute for inactivation of TP53.
11719428
2001
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
GeneticVariation
disease
CLINVAR
Our observations support the functional significance of CHK2 mutations in rare cases of LFS and suggest that such mutations may substitute for inactivation of TP53.
11719428
2001
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
GeneticVariation
disease
CLINVAR
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
11298456
2001
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.700
CausalMutation
disease
CLINVAR
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.
10617473
1999