Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.020 GeneticVariation disease BEFREE Genetic predispositions to myeloid malignancies can be classified into three categories: familial cancer syndromes associated with increased risk of various malignancies including myelodysplasia and acute myeloid leukemia such as Li-Fraumeni syndrome and constitutional mismatch repair deficiency (CMMRD); germline mutations conferring a specific increased risk of myelodysplastic syndrome and acute myeloid leukemia such as mutations in ANKRD26, CEBPA, DDX41, ETV6, GATA2, RUNX1, SRP72 genes; and finally primarily pediatric inherited bone marrow failure syndromes such as Fanconi anemia, dyskeratosis congenita, severe congenital neutropenia, Shwachman-Diamond syndrome and Diamond Blackfan anemia. 31203998 2019
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.020 Biomarker disease BEFREE Two patients with concern for FPD/AML and LFS, respectively, had RUNX1 and TP53 variants of unknown significance. 27210295 2016