Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
1.000 Biomarker disease MGD
Entrez Id: 5310
Gene Symbol: PKD1
PKD1
0.900 CausalMutation disease CLINVAR
Entrez Id: 23193
Gene Symbol: GANAB
GANAB
0.640 CausalMutation disease CLINVAR
Entrez Id: 23193
Gene Symbol: GANAB
GANAB
0.640 Biomarker disease CTD_human
Entrez Id: 11127
Gene Symbol: KIF3A
KIF3A
0.200 Biomarker disease MGD
Entrez Id: 283871
Gene Symbol: PGP
PGP
0.040 Biomarker disease BEFREE Other genes mapped to this area (16p13.3) include phosphodiesterase IB (PDE1B), hydroxyacyl-glutathione hydrolase (HAGH), phosphoglycolate phosphatase (PGP), and the gene that causes adult polycystic kidney disease (PKD1). 1285890 1993
Entrez Id: 3029
Gene Symbol: HAGH
HAGH
0.010 Biomarker disease BEFREE Other genes mapped to this area (16p13.3) include phosphodiesterase IB (PDE1B), hydroxyacyl-glutathione hydrolase (HAGH), phosphoglycolate phosphatase (PGP), and the gene that causes adult polycystic kidney disease (PKD1). 1285890 1993
Entrez Id: 5153
Gene Symbol: PDE1B
PDE1B
0.010 GeneticVariation disease BEFREE Other genes mapped to this area (16p13.3) include phosphodiesterase IB (PDE1B), hydroxyacyl-glutathione hydrolase (HAGH), phosphoglycolate phosphatase (PGP), and the gene that causes adult polycystic kidney disease (PKD1). 1285890 1993
Entrez Id: 3040
Gene Symbol: HBA2
HBA2
0.100 GeneticVariation disease BEFREE Autosomal dominant polycystic kidney disease (PKD1) is linked to the alpha-globin locus near the telomere of chromosome 16p. 1349580 1992
Entrez Id: 3039
Gene Symbol: HBA1
HBA1
0.100 GeneticVariation disease BEFREE Autosomal dominant polycystic kidney disease (PKD1) is linked to the alpha-globin locus near the telomere of chromosome 16p. 1349580 1992
Entrez Id: 5310
Gene Symbol: PKD1
PKD1
0.900 Biomarker disease BEFREE Non-PKD1 ADPKD has a much milder phenotype than that linked to PKD1. 1360045 1992
Entrez Id: 3040
Gene Symbol: HBA2
HBA2
0.100 GeneticVariation disease BEFREE We have compared the clinical features of ADPKD caused by mutations at the PKD1 locus (linked to the alpha-globin complex on chromosome 16) with those of disease not linked to the locus (non-PKD1). 1360045 1992
Entrez Id: 3039
Gene Symbol: HBA1
HBA1
0.100 GeneticVariation disease BEFREE We have compared the clinical features of ADPKD caused by mutations at the PKD1 locus (linked to the alpha-globin complex on chromosome 16) with those of disease not linked to the locus (non-PKD1). 1360045 1992
Entrez Id: 5972
Gene Symbol: REN
REN
0.100 AlteredExpression disease BEFREE Elevated levels of active renin in renal cysts may be linked to the pathogenesis of hypertension in ADPKD. 1405319 1992
Entrez Id: 5310
Gene Symbol: PKD1
PKD1
0.900 GeneticVariation disease BEFREE Since no cytogenetic abnormalities have been found in association with ADPKD, flanking genetic markers have been required to define an interval--the PKD1 region--that contains the PKD1 gene. 1577479 1992
Entrez Id: 5310
Gene Symbol: PKD1
PKD1
0.900 GeneticVariation disease BEFREE The mean (SE) age of onset of ESRD is 56.3 (1.8) years for persons with the PKD1 form of ADPKD, and 68.7 (1.7) years for affected members of families in which ADPKD is not co-inherited with PKD1 markers (P = 0.01). 1605247 1992
Entrez Id: 5310
Gene Symbol: PKD1
PKD1
0.900 GeneticVariation disease BEFREE The most likely order of six of the probes from the telomere is palpha3'HVR.64 at the designated locus D16S85, CRI-0327 at D16S63, CRI-090 at D16S45, CRI-0129 at D16S56, CRI-0133 at D16S58, and CRI-0136 at D16S60, with the PKD1 locus for ADPKD between D16S85 and D16S63. 1684301 1991
Entrez Id: 5310
Gene Symbol: PKD1
PKD1
0.900 GeneticVariation disease BEFREE Sixty-eight individuals from six Italian families in which autosomal dominant polycystic kidney disease (ADPKD) is segregating, were typed in DNA polymorphisms linked to the PKD1 locus on chromosome 16. 1684535 1991
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.060 AlteredExpression disease BEFREE In conclusion, the expression of Exo-1 in cyst-lining epithelial cells of autosomal dominant polycystic kidney disease (ADPKD) and the altered regulation of TGF-alpha and EGF receptor in these cells contribute to the hypothesis that hyperproliferation is an underlying pathogenic mechanism of ADPKD. 1739078 1992
Entrez Id: 9156
Gene Symbol: EXO1
EXO1
0.010 AlteredExpression disease BEFREE In conclusion, the expression of Exo-1 in cyst-lining epithelial cells of autosomal dominant polycystic kidney disease (ADPKD) and the altered regulation of TGF-alpha and EGF receptor in these cells contribute to the hypothesis that hyperproliferation is an underlying pathogenic mechanism of ADPKD. 1739078 1992
Entrez Id: 7039
Gene Symbol: TGFA
TGFA
0.010 AlteredExpression disease BEFREE In conclusion, the expression of Exo-1 in cyst-lining epithelial cells of autosomal dominant polycystic kidney disease (ADPKD) and the altered regulation of TGF-alpha and EGF receptor in these cells contribute to the hypothesis that hyperproliferation is an underlying pathogenic mechanism of ADPKD. 1739078 1992
Entrez Id: 5972
Gene Symbol: REN
REN
0.100 GeneticVariation disease BEFREE These results suggest that the renal renin-angiotensin system plays a central role in the alterations in renal hemodynamics and sodium management associated with the development of hypertension in ADPKD. 1921483 1991
Entrez Id: 5310
Gene Symbol: PKD1
PKD1
0.900 GeneticVariation disease BEFREE The polymorphic DNA probe VK5B (D16S94) was mapped by genetic linkage in families from the Centre d'Etude de Polymorphisme Humain (CEPH) as being in the same interval as the autosomal dominant adult polycystic kidney disease locus (PKD1). 1968038 1990
Entrez Id: 5310
Gene Symbol: PKD1
PKD1
0.900 GeneticVariation disease BEFREE We studied 17 families with autosomal dominant polycystic kidney disease to compare presymptomatic diagnosis by ultrasonography with diagnosis by genetic-linkage studies and to relate clinical variation of the disease to whether the PKD1 mutation was implicated. 2215575 1990
Entrez Id: 5972
Gene Symbol: REN
REN
0.100 Biomarker disease BEFREE The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. 2215576 1990