Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE Associated studies about eNOS polymorphisms and ADPKD were analyzed by meta-analysis. 24995932 2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE The tagSNPs of NOS3 genotypes and haplotypes did not exhibit any significant differences between controls and ADPKD patients. 24824375 2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE The distribution of C/T alleIes is significantly different between rapid and slow ADPKD progressors leading to the conclusion that the T allele of the Glu298Asp polymorphism of NOS3 gene is associated with earlier progression to ESRD in ADPKD patients. 18815450 2008
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE The endothelial nitric oxide synthase Glu298Asp and Asp29Asp genotypes were significantly more frequent in rapid progressors (9.6% (7/73) Asp/Asp, 39.7% (29/73) Asp/Glu, 50.7% (37/73) Glu/Glu) and in ADPKD group with ESRF between 40-63 years (11.3% (16/142) Asp/Asp, 41.5% (59/142) Asp/Glu, 47.2% (67/142) Glu/Glu) in comparison with slow progressors (8.8% (8/91) Asp/Asp, 24.2% (22/91) Asp/Glu, 67.0% (61/91) Glu/Glu) and with control group (8% Asp/Asp, 32% Asp/Glu, 60% Glu/Glu) (Chi-square test, p<0.05). 15287194 2004
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE Previously, a glutamic acid to aspartic acid polymorphism at residue 298 (E/D298) of the endothelial nitric oxide synthase (eNOS) gene ENOS was associated with disease severity in males with ADPKD. 12500225 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males. 11823442 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE The frequency of ecNOS a allele was significantly higher in a number limited group ADPKD patients with ESRF later than in 62 years (Chi-square test p < 0.05). 12212826 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE The a allele of the ecNOS gene polymorphism showed a significantly higher incidence among patients with ESRF caused by ADPKD. 12077489 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease LHGDN The a allele of the ecNOS gene polymorphism showed a significantly higher incidence among patients with ESRF caused by ADPKD. 12077489 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.090 GeneticVariation disease BEFREE Influence of the endothelial nitric oxide synthase polymorphism on the progression of autosomal dominant polycystic kidney disease and IgA nephropathy. 12380903 2002