Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.210 Biomarker group BEFREE Our results indicated that treatment with exogenous BDNF might constitute a potential therapeutic strategy for the treatment of bacterial meningitis. 28778220 2017
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.070 Biomarker group BEFREE In order to improve recognition of bacterial meningitis in neonates and to enable adequate management and audit, we investigated whether a systemic inflammatory response in the absence of meningitis is associated with elevated CSF protein and reduced CSF glucose levels. 29540199 2018
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.070 Biomarker group BEFREE In order to improve recognition of bacterial meningitis in neonates and to enable adequate management and audit, we investigated whether a systemic inflammatory response in the absence of meningitis is associated with elevated CSF protein and reduced CSF glucose levels. 29540199 2018
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.070 Biomarker group BEFREE The diagnosis of bacterial meningitis was made based on the clinical findings, laboratory test anomalies, CSF analysis results, and the radiological images. 27793541 2017
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.070 Biomarker group BEFREE The modified Philadelphia criteria had high sensitivity for IBI without routine CSF testing, and all infants >28 days old with bacterial meningitis were classified as high risk. 30425130 2018
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.070 Biomarker group BEFREE We focused on CSF protein concentration that is generally examined at the beginning of diagnosis and treatment of bacterial meningitis. 30424949 2019
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.070 Biomarker group BEFREE Genetic variation studies, complement level measurements in blood and CSF, and experimental work have together led to the identification of anaphylatoxin C5a as a promising treatment target in bacterial meningitis. 31373605 2019
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.070 Biomarker group BEFREE We focused on CSF protein concentration that is generally examined at the beginning of diagnosis and treatment of bacterial meningitis. 30424949 2019
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.070 Biomarker group BEFREE Several cerebrospinal fluid (CSF) biomarkers are used to distinguish between acute bacterial meningitis (BM) and viral meningitis (VM). 31480054 2019
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.070 Biomarker group BEFREE The modified Philadelphia criteria had high sensitivity for IBI without routine CSF testing, and all infants >28 days old with bacterial meningitis were classified as high risk. 30425130 2018
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.070 Biomarker group BEFREE Both CSF leukocyte and polykaryocyte can satisfactorily indicate whether the post-neurosurgical bacterial meningitis has completely been cured, 0-44/mm<sup>3</sup> is recommended as the reference range of CSF leukocyte, and the CSF polykaryocyte' s is 0-3/mm<sup>3</sup>. 30273842 2018
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.070 Biomarker group BEFREE The diagnosis of bacterial meningitis was made based on the clinical findings, laboratory test anomalies, CSF analysis results, and the radiological images. 27793541 2017
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.070 Biomarker group BEFREE Several cerebrospinal fluid (CSF) biomarkers are used to distinguish between acute bacterial meningitis (BM) and viral meningitis (VM). 31480054 2019
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.070 Biomarker group BEFREE Genetic variation studies, complement level measurements in blood and CSF, and experimental work have together led to the identification of anaphylatoxin C5a as a promising treatment target in bacterial meningitis. 31373605 2019
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.070 Biomarker group BEFREE Both CSF leukocyte and polykaryocyte can satisfactorily indicate whether the post-neurosurgical bacterial meningitis has completely been cured, 0-44/mm<sup>3</sup> is recommended as the reference range of CSF leukocyte, and the CSF polykaryocyte' s is 0-3/mm<sup>3</sup>. 30273842 2018
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Our finding suggested that genetic variations in TLR2 and TLR9 are associated with severity and prognosis of bacterial meningitis in Chinese children. 28202935 2017
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Next, we determined the genotype frequencies of TLR9 -1237 and TLR9 +2848 polymorphisms and compared these between thirteen clinical variables associated with prognostic factors predicting adverse outcome of bacterial meningitis in children. 22577991 2012
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE In conclusion, the results of our study suggest an association between the TLR9+2848 polymorphism and a reduced risk of bacterial meningitis in the codominant and recessive models. 27525854 2016
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Analysis of TLR2, TLR4, and TLR9 single nucleotide polymorphisms in children with bacterial meningitis and their healthy family members. 28487240 2017
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Two TLR9 SNPs and 4 TLR9 haplotypes were determined in 472 survivors of BM and compared to 392 healthy controls. 21258099 2011
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Carriage of one or both mutant alleles in TLR4+896 and TLR9 -1237 increases the risk for hearing loss (p = 0.0006, OR 4.1 in BM). 22662111 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.040 Biomarker group BEFREE To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD (<i>n</i> = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [<i>n</i> = 5], enteroviral meningitis [<i>n</i> = 10], nonspecific viral illness without central nervous system involvement [<i>n</i> = 10]). 29913529 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.040 AlteredExpression group BEFREE Patients with BM at the convalescent stage showed significantly diminished LRG and IL-6 levels. 30097155 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.040 Biomarker group BEFREE Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; <i>n</i> = 10) and infective endocarditis (IE; <i>n</i> = 11) compared to those with bacterial meningitis (BM; <i>n</i> = 18). 29769838 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.040 AlteredExpression group BEFREE No correlation was found between the cerebrospinal fluid VEGF and PDGF levels and IL-6 level in the IAE group, whereas a correlation was found in the BM group. 27887787 2017