Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 90768
Gene Symbol: TENM3-AS1
TENM3-AS1
0.100 GeneticVariation group GWASCAT Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis. 31092817 2019
Entrez Id: 80125
Gene Symbol: CCDC33
CCDC33
0.100 GeneticVariation group GWASCAT Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis. 31092817 2019
Entrez Id: 148581
Gene Symbol: UBE2U
UBE2U
0.100 GeneticVariation group GWASCAT Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis. 31092817 2019
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Our finding suggested that genetic variations in TLR2 and TLR9 are associated with severity and prognosis of bacterial meningitis in Chinese children. 28202935 2017
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Next, we determined the genotype frequencies of TLR9 -1237 and TLR9 +2848 polymorphisms and compared these between thirteen clinical variables associated with prognostic factors predicting adverse outcome of bacterial meningitis in children. 22577991 2012
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE In conclusion, the results of our study suggest an association between the TLR9+2848 polymorphism and a reduced risk of bacterial meningitis in the codominant and recessive models. 27525854 2016
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Analysis of TLR2, TLR4, and TLR9 single nucleotide polymorphisms in children with bacterial meningitis and their healthy family members. 28487240 2017
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Two TLR9 SNPs and 4 TLR9 haplotypes were determined in 472 survivors of BM and compared to 392 healthy controls. 21258099 2011
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Carriage of one or both mutant alleles in TLR4+896 and TLR9 -1237 increases the risk for hearing loss (p = 0.0006, OR 4.1 in BM). 22662111 2012
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.030 GeneticVariation group BEFREE Several studies have been performed to investigate the TLR2 + 2477G/A polymorphism and bacterial meningitis susceptibility. 29457581 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.030 GeneticVariation group BEFREE In a multigene analysis, combined carriership of the TLR2+2477 wild type (WT) with TLR4+896 mutant alleles increases the risk of hearing loss (p<0.0001, OR 5.7 in BM and p= 0.0001, OR 7.6 in MM). 22662111 2012
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.030 GeneticVariation group BEFREE Our finding suggested that genetic variations in TLR2 and TLR9 are associated with severity and prognosis of bacterial meningitis in Chinese children. 28202935 2017
Entrez Id: 566
Gene Symbol: AZU1
AZU1
0.020 GeneticVariation group BEFREE <i>Neisseria meningitidis</i> is the most common cause of bacterial meningitis in children and young adults worldwide.A 4-component vaccine against <i>N. meningitidis</i> serogroup B (MenB) disease (MenB-4C [Bexsero]; GSK) combining factor H binding protein (fHBP), neisserial heparin binding protein (NHBA), neisserial adhesin A (NadA), and PorA-containing outer membrane vesicles was recently approved for use in the United States and other countries worldwide. 29152576 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.020 GeneticVariation group BEFREE In this study, we analyzed the associations between the SNPs TNF -308G > A, TNF -857C > T, IL-8 -251A > T and BM and investigated gene-gene interactions, including the SNPs that we published previously. 26316174 2015
Entrez Id: 4048
Gene Symbol: LTA4H
LTA4H
0.010 GeneticVariation group BEFREE We genotyped the LTA4H promoter region SNP (rs17525495) in 390 bacterial meningitis patients and 751 population controls. rs17525495 was associated with susceptibility to bacteriologically confirmed bacterial meningitis (P = 0.01, OR 1.27 95% confidence interval [CI] 1.05-1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment. 25799317 2015
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.010 GeneticVariation group LHGDN These results suggest that codon 54 polymorphism in the MBL gene may play a role in susceptibility to bacterial meningitis in children. 17990579 2008
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
0.010 GeneticVariation group BEFREE In conclusion, we identified an association between a genetic variant in the β2-adrenoceptor and increased susceptibility to bacterial meningitis. 22624056 2012
Entrez Id: 142
Gene Symbol: PARP1
PARP1
0.010 GeneticVariation group BEFREE In recent papers published by our group, we described the associations between the single nucleotide polymorphisms (SNPs) AADAT +401C > T, APEX1 Asn148Glu, OGG1 Ser326Cys and PARP1 Val762Ala and BM. 26316174 2015
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.010 GeneticVariation group BEFREE <i>Neisseria meningitidis</i> is the most common cause of bacterial meningitis in children and young adults worldwide.A 4-component vaccine against <i>N. meningitidis</i> serogroup B (MenB) disease (MenB-4C [Bexsero]; GSK) combining factor H binding protein (fHBP), neisserial heparin binding protein (NHBA), neisserial adhesin A (NadA), and PorA-containing outer membrane vesicles was recently approved for use in the United States and other countries worldwide. 29152576 2019
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.010 GeneticVariation group BEFREE Streptococcus pyogenes (Group A streptococcus, GAS) is a rare cause of bacterial meningitis, accounting for less than 1% of cases. 24177305 2013
Entrez Id: 328
Gene Symbol: APEX1
APEX1
0.010 GeneticVariation group BEFREE A higher frequency (P<0.05) of APE1 Glu allele in bacterial meningitis (BM) and aseptic meningitis (AM) patients was observed. 21651918 2011
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.010 GeneticVariation group BEFREE For the SNP OGG1 Ser326Cys, the genotype Cys/Cys was more frequent (P<0.05) in BM group. 21651918 2011
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1
0.010 GeneticVariation group BEFREE Streptococcus pyogenes (Group A streptococcus, GAS) is a rare cause of bacterial meningitis, accounting for less than 1% of cases. 24177305 2013
Entrez Id: 7098
Gene Symbol: TLR3
TLR3
0.010 GeneticVariation group BEFREE We investigated whether bacterial meningitis (BM) in children was associated with gene polymorphisms in TLR2 (rs3804099), TLR3 (rs3775291 and rs3775290) and TLR9 (rs352139 and rs352140). 28202935 2017
Entrez Id: 2588
Gene Symbol: GALNS
GALNS
0.010 GeneticVariation group BEFREE Streptococcus pyogenes (Group A streptococcus, GAS) is a rare cause of bacterial meningitis, accounting for less than 1% of cases. 24177305 2013