Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.030 Biomarker group BEFREE Dexamethasone inhibits lipopolysaccharide-induced synthesis of the cytokine, interleukin-1 beta, in cerebrospinal fluid of patients with bacterial meningitis. 7593467 1995
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.030 Biomarker group BEFREE Interleukin-1beta (IL-1beta) is considered an important mediator in the pathogenesis of septic shock or bacterial meningitis. 9242541 1997
Entrez Id: 719
Gene Symbol: C3AR1
C3AR1
0.010 Biomarker group BEFREE However, a strong C3aR staining was evident in areas of inflammation in multiple sclerosis and bacterial meningitis. 9531317 1998
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.020 AlteredExpression group BEFREE Augmented proteolytic activity of MMP-9 could also be demonstrated in CSF samples obtained from patients with bacterial meningitis, underlining the clinical relevance of our experimental findings. 10430840 1999
Entrez Id: 929
Gene Symbol: CD14
CD14
0.010 Biomarker group BEFREE The origin and function of soluble CD14 in experimental bacterial meningitis. 10202018 1999
Entrez Id: 6374
Gene Symbol: CXCL5
CXCL5
0.010 Biomarker group LHGDN During bacterial meningitis, CXCL5 is elevated in CSF, where it is involved in the recruitment of neutrophils to the central nervous system. 14644041 2003
Entrez Id: 2633
Gene Symbol: GBP1
GBP1
0.010 Biomarker group LHGDN Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis. 16936281 2006
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.020 Biomarker group BEFREE Moreover, patients suffering from bacterial meningitis showed increased intrathecal synthesis of TRAIL. 17571163 2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.020 AlteredExpression group LHGDN Furthermore, the results of this study revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis. 19141395 2008
Entrez Id: 820
Gene Symbol: CAMP
CAMP
0.010 Biomarker group BEFREE We found antimicrobial peptides (human cathelicidin LL-37) in the CSF of patients with bacterial meningitis but not in control CSF. 18957897 2008
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.010 GeneticVariation group LHGDN These results suggest that codon 54 polymorphism in the MBL gene may play a role in susceptibility to bacterial meningitis in children. 17990579 2008
Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2
0.010 AlteredExpression group LHGDN Furthermore, the results of this study revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis. 19141395 2008
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.010 AlteredExpression group LHGDN Furthermore, the results of this study revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis. 19141395 2008
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.010 AlteredExpression group LHGDN This study provides comprehensive information regarding the cell specificity of matrix metalloproteinases (MMP-2, MMP-9) and their binding tissue inhibitors (TIMP-1, TIMP-2) in the central nervous system during viral and bacterial meningitis. 19141395 2008
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Two TLR9 SNPs and 4 TLR9 haplotypes were determined in 472 survivors of BM and compared to 392 healthy controls. 21258099 2011
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.020 Biomarker group BEFREE Moreover, reduction in the levels of IL-6, IL-1Ra, MCP-1/CCL2 and IL-8/CXCL8 was observed in the presence of APE1 Glu allele in BM patients. 21651918 2011
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.010 Biomarker group BEFREE We conclude that Tpo acts as a mediator of neuronal damage in bacterial meningitis. 21149592 2011
Entrez Id: 328
Gene Symbol: APEX1
APEX1
0.010 GeneticVariation group BEFREE A higher frequency (P<0.05) of APE1 Glu allele in bacterial meningitis (BM) and aseptic meningitis (AM) patients was observed. 21651918 2011
Entrez Id: 8685
Gene Symbol: MARCO
MARCO
0.010 Biomarker group BEFREE The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis. 21299846 2011
Entrez Id: 2358
Gene Symbol: FPR2
FPR2
0.010 Biomarker group BEFREE The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis. 21299846 2011
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.010 GeneticVariation group BEFREE For the SNP OGG1 Ser326Cys, the genotype Cys/Cys was more frequent (P<0.05) in BM group. 21651918 2011
Entrez Id: 51166
Gene Symbol: AADAT
AADAT
0.010 GeneticVariation group BEFREE A significant decrease (p < 0.05) in TNF-α, IL-1β, IL-6, MIP-1αCCL3 and MIP-1β/CCL4 levels was observed in BM patients homozygous (TT) to the SNP AADAT+401C/T. 21473761 2011
Entrez Id: 6351
Gene Symbol: CCL4
CCL4
0.010 AlteredExpression group BEFREE A significant decrease (p < 0.05) in TNF-α, IL-1β, IL-6, MIP-1αCCL3 and MIP-1β/CCL4 levels was observed in BM patients homozygous (TT) to the SNP AADAT+401C/T. 21473761 2011
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Next, we determined the genotype frequencies of TLR9 -1237 and TLR9 +2848 polymorphisms and compared these between thirteen clinical variables associated with prognostic factors predicting adverse outcome of bacterial meningitis in children. 22577991 2012
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.060 GeneticVariation group BEFREE Carriage of one or both mutant alleles in TLR4+896 and TLR9 -1237 increases the risk for hearing loss (p = 0.0006, OR 4.1 in BM). 22662111 2012