Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Among individuals with essential hypertension certain relationships were documented between rs5182 and rs5186 polymorphisms of AGTR1 gene and rs1799998 polymorphism of CYP11B2 gene on one hand and the volume of carotid bodies on one other. 29627490 2018
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE This case-control study was aiming to investigate the relationship between the aldosterone synthase gene (CYP11B2) biallelic polymorphism in the promoter at position -344 (-344C/T) with essential hypertension and left ventricular hypertrophy in the Egyptian population. 30561227 2018
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Single-locus analysis revealed significant association of CYP11B2 C-344T and Lys173Arg polymorphisms with EHT (p < 0.05). 27935319 2017
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 Biomarker disease BEFREE This study aimed to assess the association between human CYP11B2 and EH using a haplotype-based case-control study. 28953657 2017
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE When subgrouped by sex, males with the t allele of REN Taq I had decreased risk for EH (OR: 0.529), and those with AGT -6G and CYP11B2 -344 C had increased risk for EH (OR: 1.498; 1.449). 26305278 2016
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Our study is aimed at evaluating the contribution of <i>CYP11B2</i> promoter methylation to the risk of EH. 28078278 2016
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Our study suggests that there is lack of association between C-344T polymorphism of CYP11B2 gene and EH in Dongxiang and Han populations, whereas the polymorphism was correlated with EH in female population of Tibetan. 27149293 2016
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 Biomarker disease BEFREE Our results suggest that the down-regulation of ANP gene expression at mRNA and protein levels and up-regulated CYP11B2 protein expression levels may be correlated with the essential hypertension and could serve as circulating prognostic biomarkers for essential hypertension. 25917967 2015
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 Biomarker disease BEFREE Aldosterone synthase (CYP11B2) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH). 25208931 2015
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE These data demonstrated that ADRB3 rs4994 and CYP11B2 rs1799998 were significantly closely associated with EH in northern Han Chinese individuals. 25099490 2014
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE The -344C/T polymorphism in the CYP11B2 gene is associated with essential hypertension in the Chinese. 23204185 2014
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE The locus encompassing the corticosteroidogenic genes CYP11B2 and CYP11B1 is of potential importance in essential hypertension. 23150505 2013
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Relationship between -344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension. 21846681 2011
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE After 6 weeks, the results showed that the ACE I/D polymorphism, not the CYP11B2 -344T/C polymorphism, was associated with systolic blood pressure (SBP) response to HCTZ (P = 0.009) in the Han Chinese population with essential hypertension, with no interaction. 21269061 2011
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 Biomarker disease BEFREE To address this issue, we carried out a haplotype-based, case-control study to explore the association between a human CYP11B2 gene and essential hypertension (EH) in the southwest Han population of China (n = 1020 individuals). 21269059 2011
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 Biomarker disease BEFREE Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China. 21127960 2011
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE In this Han Chinese population, the -344T/C polymorphism of the CYP11B2 gene was found to be associated with EH and glucose homeostasis, both of which might be mediated by plasma aldosterone levels, insulin sensitivity and β-cell function. 21682760 2011
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Current large sample analysis did not support the association between the etiology of essential hypertension and CYP11B2 - 344 C/T polymorphism in Han Chinese. 20662731 2010
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Interaction between the C(-344)T polymorphism of CYP11B2 and alcohol consumption on the risk of essential hypertension in a Chinese Mongolian population. 20878543 2010
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE In this case-control study we examined the association between CYP11B2 C-344T polymorphism and essential hypertension in south Indian Tamil population. 20966514 2010
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Our findings support the notion that the CYP11B2 -344C/T polymorphism is associated with essential hypertension. 19407459 2009
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Association of the -344T/C aldosterone synthase gene variant with essential hypertension. 19093739 2009
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 AlteredExpression disease BEFREE The intron-2 conversion polymorphism of CYP11B2 was suggested to lead to overexpression of the gene, and may therefore have potential to predict the blood pressure response of patients with essential hypertension to angiotensin-converting enzyme inhibitors (ACEIs). 18192839 2008
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis. 17143166 2007
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.100 GeneticVariation disease BEFREE Although polymorphisms in renin-angiotensin-aldosterone (RAA) system genes for angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AT1 A/C1166), and aldosterone synthase (CYP11B2-344T/C) have been major targets for genetic investigation in association with essential hypertension (EH), the influence of these genetic factors is still to be determined. 17190732 2007