| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | This study aimed to investigate the relationship between serum leptin and HRR in Chinese untreated EH patients. | 28448190 | 2017 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Our findings support the contributory role of the II/I polymorphism in leptin gene in the pathogenesis of hypertension, and this role was more evident in Asians and for essential hypertension. | 25475696 | 2015 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Evaluation of leptin and leptin receptor gene 3' UTR polymorphisms in essential hypertension. | 24171506 | 2014 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Conflicting data suggest an association between leptin gene polymorphisms and essential hypertension independently of obesity. | 17114907 | 2006 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Essential hypertension is associated with increased plasma leptin levels and decreased human soluble leptin receptor (hsLR) concentration. | 17086020 | 2006 | ||||
|
0.090 | Biomarker | disease | BEFREE | Five candidate genes including the lipoprotein lipase, leptin, leptin receptor, alpha-adducin and beta3 adrenergic receptor were selected to examine their possible contribution to essential hypertension (EH) in a Chinese population. | 12571619 | 2003 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | The aim of our study was to test the hypothesis that elevated plasma leptin and insulin levels as well as systolic blood pressure (SBP) and diastolic blood pressure (DBP) and increased resting HR preexist in the healthy offspring of patients with EH. | 10539824 | 1999 | ||||
|
0.090 | Biomarker | disease | BEFREE | These results suggest that the OB gene is not a major contributor to the phenotype of essential hypertension in African Americans, although a minor contribution to the phenotype of extreme obesity in this group cannot be ruled out. | 9622134 | 1998 | ||||
|
0.090 | Biomarker | disease | BEFREE | Is there a role for the ob gene product leptin in essential hypertension? | 9832173 | 1998 |