Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Associations of methylenetetrahydrofolate reductase C677T genotype with blood pressure levels in Chinese population with essential hypertension. 29436860 2018
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE This study suggests that both tHcy and the MTHFR C677T gene polymorphism may be important determinants of the incidence of dyslipidemia in Chinese patients with essential hypertension. 26442927 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE The aim of this study was to investigate the association between the MTHFR C677T polymorphism and essential hypertension in a Cameroonian population (Bantu ethnic group) of the South West Region. 27051013 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Benazepril may cause an increase in plasma Hcy levels among patients with hypertension with low baseline Hcy levels, while effect modification by MTHFR C677T genotypes on the changes in Hcy levels in response to benazepril was not significant among patients with essential hypertension. 25550183 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Functional Polymorphism rs13306560 of the MTHFR Gene Is Associated With Essential Hypertension in a Mexican-Mestizo Population. 26022245 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: a systematic review and meta-analysis. 25458833 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE The purpose of this study was to examine the carriage of gene combinations of the ACE (insertion/deletion [I/D]), MTHFR 677T and 1298C, and lipid profiles in patients with essential hypertension (EH) in Turkey. 21699409 2011
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE There was no significant association between MTHFR C677T genotypes and changes in Hcy levels in response to enalapril among subjects with essential hypertension. 20669348 2010
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE No significant association between MTHFR C677T genotypes and changes in Hcy levels in response to antihypertensive was observed in EH patients. 18200034 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE In this study, we measured serum folate, serum vitamin B12, and plasma homocysteine and determined the MTHFR C677T genotype of 78 patients with essential hypertension, 100 patients with coronary artery disease, and 100 healthy subjects. 18068006 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE The 677C --> T polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene is associated with elevated homocysteine level in the general population, and therefore it has been hypothesized to be a risk factor for the development of renal failure in the course of essential hypertension. 16280279 2005