Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 Biomarker disease BEFREE In addition, serum ACE2 (183.57 pg/ml; vs. 151.78 pg/ml; p = 0.02) and chymase (68.5 pg/ml; vs. 23.66 pg/ml; p = 0.034) were significantly higher in patients with uncontrolled EH than controlled EH in response to ACE-inhibitory therapy. 30307755 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE In conclusion, the ACE2 variant rs2074192 was associated with EH and EH with CAS ≥50%, while 3 ACE2 variants (rs4240157, rs4646155, and rs4830542) were associated with EH- and hypertension-related AF and left atrial remodeling in south Xinjiang, China. 30542083 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 AlteredExpression disease BEFREE And the serum ACE2 activity can predict the development of cardiac dysfunction in EH patients. 30335025 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE The ACE2 rs4646188 variant may be a potential and optimal genetic susceptibility marker for EH, dyslipidemia and its related ischemic stroke. 30342552 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 Biomarker disease BEFREE Angiotensin-converting enzyme 2 (ACE2) plays an important role in the development of essential hypertension (EH). 28895159 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 PosttranslationalModification disease BEFREE Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension. 28440441 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE These results suggest that the ACE2 G8790A and rs2106809 polymorphisms may be associated with EH risk. 25237167 2015
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE Among females, ACE I/D and ACE2 rs2106809 polymorphisms, while among males, ACE2 rs2106809 polymorphism and alcohol consumption are associated with essential hypertension in the study population. 24112034 2014
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE The current meta-analysis provided solid evidence suggesting that ACE2 gene polymorphism G8790A was probably a genetic risk factor for essential hypertension across different ethnic populations in female subjects and in Han-Chinese male subjects. 22297693 2012
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE The meta-analysis suggests that ACE2 G8790A polymorphism may not be a genetic risk factor for essential hypertension in a Chinese Han population. 19286756 2009
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. 17473847 2007
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 Biomarker disease BEFREE The results provided evidence that genetic variants of UTS2 and ACE2 may play a role in the development of essential hypertension in these populations. 16866021 2007
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. 15233982 2004
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.100 GeneticVariation disease BEFREE Submaximal exercise (on a treadmill, using the Naughton protocol at 75% of maximal heart rate) was performed in 34 patients homozygous for the ACE I/D polymorphism (ACE II and ACE DD) with untreated essential hypertension (II = 19, DD = 15). 12165743 2002