Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 GeneticVariation disease BEFREE This study focuses on investigating the potential variants on SCN5A, KCNQ1, and KCNH2 contributing to AMI with VA in a Chinese population. 31751991 2020
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 Biomarker disease BEFREE We confirmed that the optical recordings of APs in single cells and monolayers derived from control- and LQT1-iPSC-CMs can be used to assess arrhythmogenicity, supporting the feasibility of membrane potential dye-based high-throughput screening to study ventricular arrhythmias caused by genetic channelopathy or cardiotoxic drugs. 30956674 2019
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 GeneticVariation disease BEFREE In addition, the KCNQ1 S140G mutation can induce ventricular arrhythmia and lessen ventricular contractility under re-entrant conditions. 30108508 2018
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 GeneticVariation disease BEFREE Long QT syndrome 1 (LQT1) mutations in KCNQ1 that decrease cardiac IKs (slowly activating delayed rectifier K(+) current) underlie ventricular arrhythmias and sudden death. 25344363 2014
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 Biomarker disease BEFREE Long QT syndrome (LQTS) is a cardiac channelopathy predisposing to syncope and sudden death secondary to LQT-triggered ventricular arrhythmias. 23095322 2014
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 Biomarker disease BEFREE In LQT1 subtype of inherited long QT syndrome, repolarization abnormalities originating from defective I(Ks) render patients vulnerable to ventricular arrhythmia during sudden sympathetic activation. 18365896 2008
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 GeneticVariation disease BEFREE As abrupt sympathetic activation triggers ventricular arrhythmias that may cause syncopal attacks and sudden death in LQT1 patients, we investigated whether two known beta1-adrenergic receptor polymorphisms were associated with the duration of QT interval or history of symptoms in LQT1. 17023080 2007
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 Biomarker disease BEFREE Our data indicate that in healthy individuals, CaM binding to KCNQ1 is essential for correct channel folding and assembly and for conferring Ca(2+)-sensitive IKS-current stimulation, which increases the cardiac repolarization reserve and hence prevents the risk of ventricular arrhythmias. 16556865 2006
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 Biomarker disease BEFREE Genetic mutations in the alpha- (KCNQ1) and beta- (KCNE1) subunits of I(Ks) underlie Long QT Syndrome type 1 and 5 (LQT-1 and LQT-5), respectively, and predispose carriers to the development of polymorphic ventricular arrhythmias and sudden cardiac death. beta-adrenergic stimulation increases I(Ks) and results in rate dependent AP shortening, a control system that can be disrupted by some mutations linked to LQT-1 and LQT-5. 15731462 2005
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 Biomarker disease BEFREE Mutations in the human minK gene KCNE1 have been linked to autosomal dominant and autosomal recessive long-QT (LQT) syndrome, a cardiac condition predisposing to ventricular arrhythmias. minK and KvLQT1, the LQT1 gene product, form a native cardiac K+ channel that regulates the slowly delayed rectifier potassium current I(Ks). 11692163 2001
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 GeneticVariation disease BEFREE Mutations in HERG or KVLQT1 genes predispose affected individuals to ventricular arrhythmias and sudden death. 9476573 1997
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
0.200 GeneticVariation disease CLINVAR