Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 Biomarker disease BEFREE This report describes a 43-year-old patient with FLT3-internal tandem duplication (FLT3-ITD) positive acute myeloid leukemia who initially presented with leukocytosis and concern for acute leukemia. 29558838 2019
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 AlteredExpression disease BEFREE In this Mini-Review, we highlight the role of FLT3 overexpression in acute leukaemia and discuss emerging mechanisms accounting for this upregulation. 31201827 2019
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 Biomarker disease BEFREE FLT3-mutated acute myeloid leukemia (AML), despite not being recognized as a distinct entity in the World Health Organization (WHO) classification system, is readily recognized as a particular challenge by clinical specialists who treat acute leukemia. 27872057 2017
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 Biomarker disease BEFREE To determine a safe and biologically active dose of quizartinib (AC220), a potent and selective class III receptor tyrosine kinase (RTK) FLT3 inhibitor, in combination with salvage chemotherapy in children with relapsed acute leukemia. 26920889 2016
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE This is the first report of acute leukemia induced by an activating FLT3 mutation in C57BL/6J mice. 26891877 2016
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE We previously generated a knock-in mouse, harboring an internal tandem duplication at the endogenous Flt3 locus, which develops a fatal myeloproliferative neoplasm (MPN), but fails to develop acute leukemia, suggesting additional mutations are necessary for transformation. 27636998 2016
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE Somatic gene mutations associated with acute leukemia including FLT3, RAS and PTPN11 were revisited. 24991719 2015
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 Biomarker disease BEFREE Correlation between FLT3-ITD status and clinical, cellular and molecular profiles in promyelocytic acute leukemias. 25530565 2015
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 AlteredExpression disease BEFREE Gö6976, a FLT3 kinase inhibitor, exerts potent cytotoxic activity against acute leukemia via inhibition of survivin and MCL-1. 24735609 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE Detection and biological characteristic of FLT3 gene mutations in children with acute leukemia. 24724602 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE FLT3 is one of the most frequently mutated genes in acute leukemias. 24269847 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 Biomarker disease BEFREE Activating mutations of class III receptor tyrosine kinases (RTK) FLT3, PDGFR and KIT are associated with multiple human neoplasms including hematologic malignancies, for example: systemic mast cell disorders (KIT), non-CML myeloproliferative neoplasms (PDGFR) and subsets of acute leukemias (FLT3 and KIT). 23497317 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE The FLT3 molecular marker is listed as a prognostic factor, an important leukaemogenic marker in acute leukemias, also the polymorphism (G1082A) of the IL10 interleukin can to present pleiotropic effects in many diseases and could is associated to development of ALL. 23086275 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE We report the results of flow cytometry immunophenotypic analysis in 42 cases of T-ALL and T/myeloid acute leukemia also assessed for FLT3 mutation. 22261446 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE Mll(PTD/WT):Flt3(ITD/WT) mice developed acute leukemia with 100% penetrance, at a median of 49 weeks. 22674806 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE Recent work has shown that FLT3 activating mutations can collaborate with a Nup98-HoxD13 mutation to induce an aggressive acute leukemia. 22643831 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 Biomarker disease BEFREE FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. 21272320 2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE We correlated the impact of FLT3 mutations and its expression with age, WHO 2008 classification and treatment outcome in 531 childhood acute leukaemias. 21387358 2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE Fms-like tyrosine kinase 3 mutations in childhood acute leukemias and their association with prognosis. 21133602 2010
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE Prevalence and prognostic significance of FLT3 gene mutations in patients with acute leukaemia: analysis of patients from the Shanghai Leukaemia Co-operative Group. 20515557 2010
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 Biomarker disease BEFREE Bench to bedside targeting of FLT3 in acute leukemia. 20370649 2010
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 Biomarker disease BEFREE These results suggest that Survivin regulates expansion of ITD-Flt3-transformed HPCs with self-renewal capability and development of ITD-Flt3(+) acute leukemia and that antagonizing Survivin may provide therapeutic benefit for patients with acute leukemia expressing ITD-Flt3. 19411632 2009
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns. 17943971 2008
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 AlteredExpression disease BEFREE Surface expression of FLT3 protein was correlated with high percentage of bone marrow blasts and with FLT3 mRNA expression (r=0.366, P<0.001) in acute leukemia. 18925699 2008
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.100 GeneticVariation disease BEFREE To characterize the mechanism of transformation by FLT3-ITDs, we sequenced the juxtamembrane region (JM) of FLT3 from 284 patients with acute leukemias. 17387224 2007