Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 Biomarker disease BEFREE Rearrangements of the MLL gene (ALL1, HRX, and Hrtx) located at chromosome band 11q23 are commonly involved in adult and pediatric cases of primary acute leukemias and also found in cases of therapy-related secondary leukemias. 15618964 2005
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 Biomarker disease BEFREE Rearrangements of the mixed-lineage leukemia gene MLL1 (MLL, HRX, ALL1), the human homologue of the Drosophila gene trithorax, are associated with aggressive acute leukemias in both children and adults. 15663355 2004
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 AlteredExpression disease BEFREE The mixed lineage leukaemia gene, MLL (also called HRX, ALL-1) in acute leukaemia is fused to at least 16 identified partner genes that display diverse structural and biochemical properties. 10764144 2000
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 Biomarker disease BEFREE The HRX gene (also called MLL, ALL-1, and Htrx) at chromosome band 11q23 is associated with specific subsets of acute leukemias through translocations that result in its fusion with a variety of heterologous partners. 9418860 1998
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 Biomarker disease BEFREE The ALL1 gene (also called MLL, HRX, or Htrx1) at the cytogenetic band 11q23 is consistently altered by chromosome rearrangements in acute leukemias (ALs) of early infancy, in ALs developed after exposure to topoisomerase (topo) II-inhibitory drugs, and in a small subset of de novo ALs in children and adults. 9230194 1997
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 GeneticVariation disease BEFREE The human ALL-1/MLL/HRX gene on chromosome 11q23 is the site of many locally clustered chromosomal alterations associated with several types of acute leukemias, including deletions. partial duplications and reciprocal translocations. 9477123 1997
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 GeneticVariation disease BEFREE Translocations involving the HRX/ALL1 locus at chromosomal region 11q23 are among the most frequent cytogenetic abnormalities in acute leukemias. 9041173 1997
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 GeneticVariation disease BEFREE Another kind of HRX alteration seen in human acute leukemia is a partial duplication of the NH2 part of the HRX locus. 7658717 1995
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 GeneticVariation disease BEFREE We and others have recently reported a high frequency (70-80%) of ALL-1 (MLL, HRX, HTRX) gene rearrangements in infants with acute leukemias (AL) aged less than 1 year. 7885037 1995
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 GeneticVariation disease BEFREE Seven patients with acute leukemia and translocation involving band 11q23 have been studied by fluorescence in situ hybridization (FISH) using YAC probes spanning the HRX gene. 8152254 1994
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 Biomarker disease BEFREE Recent studies by ourselves and others have demonstrated breakpoint clustering in acute leukemias bearing translocations involving 11q23, and a Drosophila trithorax gene homologue (called MLL, HRX, or ALL-1) has been shown to span the 11q23 breakpoints of these translocations. 8282816 1994
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 Biomarker disease BEFREE Disruption of HRX as a result of chromosomal translocation is thought to contribute to the leukaemogenic process; this may occur in utero giving rise to infant acute leukaemia or may be induced by epipodophyllotoxic drugs resulting in secondary leukaemia. 7920216 1994
Entrez Id: 7974
Gene Symbol: HRX
HRX
0.100 Biomarker disease BEFREE These features are similar to predicted t(11;19) fusion proteins, suggesting that HRX consistently contributes a novel DNA-binding motif to at least two different chimeric proteins in acute leukemias. 8443374 1993