Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 Biomarker disease BEFREE The MLLT10 (formerly AF10) gene is the fourth most common KMT2A fusion partner across all acute leukemias and requires at least 3 breaks to form an in-frame KMT2A/MLLT10 fusion due to the opposite orientation of each gene. 30707474 2019
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 Biomarker disease BEFREE KMT2A-MLLT10 is one of the common chimeric genes diagnosed in acute leukemia with KMT2A rearrangement (8%), especially in acute myeloid leukemia (AML; 18%). 30624859 2019
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 GeneticVariation disease BEFREE The PICALM-MLLT10 fusion gene, generated by the t(10;11)(p12-13;q14-21) translocation, is a rare but recurrent event in acute leukemias. 22871473 2012
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 Biomarker disease BEFREE CALM-AF10 mice infected with the MOL4070LTR retrovirus developed acute leukemia, and ligation-mediated polymerase chain reaction was used to identify retroviral insertions at 19 common insertion sites, including Zeb2, Nf1, Mn1, Evi1, Ift57, Mpl, Plag1, Kras, Erg, Vav1, and Gata1. 20007546 2010
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 Biomarker disease BEFREE The case report and literature review here (including discussion of the poor prognosis and of management, including CNS prophylaxis) are intended to raise awareness and to inform about PICALM-MLLT10 in acute leukemia. 20875875 2010
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 Biomarker disease BEFREE The role of CALM-AF10 gene fusion in acute leukemia. 18094714 2008
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 AlteredExpression disease BEFREE Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice. 17804713 2007
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 AlteredExpression disease BEFREE We also identified overexpression of HOXA9, a gene essential to myeloid differentiation that is expressed in PICALM-MLLT10 and MLL-rearranged acute leukemias. 16518848 2006
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 Biomarker disease BEFREE Dual-color split signal fluorescence in situ hybridization assays for the detection of CALM/AF10 in t(10;11)(p13;q14-q21)-positive acute leukemia. 16956826 2006
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 Biomarker disease BEFREE The endogenous function of human AF10 is not known, but may be vital to its role in acute leukemia. 15258852 2004
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 GeneticVariation disease BEFREE t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines. 11477655 2001
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 GeneticVariation disease BEFREE The MLL-AF10 fusion produced by the t(10;11)(p12;q23) or ins(10;11)(p12;q23q13) occurs in a small percentage of acute leukemias, most commonly acute myelogenous leukemia (AML) of the M5 FAB subtype. 11187895 2000
Entrez Id: 8028
Gene Symbol: MLLT10
MLLT10
0.100 Biomarker disease BEFREE MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis. 9616163 1998