Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE These mutations include JAK2, CALR and MPL mutations as the main disease drivers, mutations driving clonal expansion, and mutations that contribute to progression of chronic MPNs to myelodysplasia and acute leukemia. 31741139 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE MDM2 inhibitors that activate p53 and induce apoptosis are currently being developed for potential treatment of acute leukemia. 30389549 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation. 26440941 2015
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE A high JAK2(V617F) allele burden was correlated with the transformation to myelofibrosis (p<0.0001), but not with the transformation to acute leukemia. 22818858 2013
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE More recently, aberrations involving the JAK2 gene have also been reported in lymphoid diseases, including acute leukemia and lymphomas. 23991929 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia. 22930568 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE Mutations in p53 are rarely found in these diseases before acute leukemia transformation, but this does not rule out a role for p53 deregulation in disease progression. 21785463 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE TP53 codon 72 polymorphism and risk of acute leukemia. 22502699 2012
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE This study aimed to detect whether any association exists between genetic polymorphisms in JAK2 gene and individual susceptibility to acute leukemia. 22168550 2012
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE Translocations involving the JAK2 locus are of oncogenic importance in acute leukemias, myelodysplastic/myeloproliferative diseases and T-cell lymphomas. 21091042 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression disease BEFREE The oncoprotein inhibitory member of the ASPP family (iASPP) is a key inhibitor of the p53 tumor suppressor and is upregulated in patients with acute leukemia and breast carcinoma. 21391736 2011
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE JAK2 V617F mutation was detected after transformation to CMML in 1 of them; in the other, a novel translocation t(5;12)(p13;q24) was observed at the time of progression to acute leukemia. 21658659 2011
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 Biomarker disease BEFREE In addition, less common aberrations (particularly gene fusions) involving JAK2 have been described in acute leukemias. 18618714 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression disease BEFREE We demonstrated that acute leukaemia, myeloblastic (AML) and lymphoblastic (ALL), is associated with significantly elevated levels of p53 and Bax mRNA in leukaemic cells. 19020783 2008
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 Biomarker disease BEFREE Constitutively activated mutants of the non-receptor tyrosine kinases (TK) ABL1 (Abelson murine leukemia viral (v-abl) homolog (1) protein) and JAK2 (JAnus Kinase 2 or Just Another Kinase 2) play a central role in the pathogenesis of clinically and morphologically distinct chronic myeloproliferative disorders but are also found in some cases of de novo acute leukemia and lymphoma. 18528425 2008
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE ETV6-JAK2, PCM1-JAK2, BCR-JAK2) mutations have respectively been described in acute megakaryocytic leukemia and acute leukemia/chronic myeloid malignancies. 18297515 2008
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE Despite this progress, many questions remain unsolved, including how a single JAK2 mutation causes three different MPD phenotypes, what other genes might be involved in the pathogenesis, and what are the factors determining the progression to acute leukemia. 18024602 2007
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE We focused our study on the Janus kinase 2 (JAK2) gene in 90 cases of acute leukemia. 17068151 2007
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE Activation of JAK2 by chromosomal translocation or point mutation is a recurrent event in hematopoietic malignancies, including acute leukemias and myeloproliferative disorders. 17077140 2006
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 GeneticVariation disease BEFREE JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. 16037387 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE To gain further insight into the role of P53 network in the evolution of acute leukemias, the P53, MDM2, BCL2 and BAX mRNAexpressions in portion samples from patients with ALL and AML were analyzed using multiplex RT-PCR. 16059649 2005
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.200 Biomarker disease BEFREE A translocation generating the constitutively activated fusion protein PCM1-JAK2 has also been recently found in atypical chronic myelogenous leukemia and acute leukemia. 16007127 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE Germ-line p53 mutations are associated with dominantly inherited Li-Fraumeni syndrome (LFS), which features early-onset sarcomas of bone and soft tissues, carcinomas of the breast and adrenal cortex, brain tumors, and acute leukemias. 11219776 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation disease BEFREE Microsatellite instability and p53 mutations are associated with abnormal expression of the MSH2 gene in adult acute leukemia. 10397740 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker disease BEFREE Mechanisms of relapse in acute leukaemia: involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemia. 10098750 1999