Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.320 GeneticVariation disease BEFREE In conclusion, mutations in the gene encoding surfactant protein C are not common in sporadic cases of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia, suggesting that the mutated gene does not play an important role in the pathogenesis of these forms of idiopathic interstitial pneumonia. 17005585 2007
Entrez Id: 6440
Gene Symbol: SFTPC
SFTPC
0.320 GeneticVariation disease BEFREE Using a candidate gene approach, we found a heterozygous exon 5 + 128 T-->A transversion of SFTPC in a large familial pulmonary fibrosis kindred, including adults with usual interstitial pneumonitis and children with cellular nonspecific interstitial pneumonitis. 11991887 2002
Entrez Id: 653509
Gene Symbol: SFTPA1
SFTPA1
0.310 GeneticVariation disease BEFREE Germline SFTPA1 mutation in familial idiopathic interstitial pneumonia and lung cancer. 26792177 2016
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.310 Biomarker disease BEFREE Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about similarities or differences of affected individuals.115 patients with mutations in telomerase reverse transcriptase (TERT) (n=75), telomerase RNA component (TERC) (n=7), regulator of telomere elongation helicase 1 (RTEL1) (n=14) and poly(A)-specific ribonuclease (PARN) (n=19) were identified and clinical data were analysed.Approximately one-half (46%) had a multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF); others had unclassifiable lung fibrosis (20%), chronic hypersensitivity pneumonitis (12%), pleuroparenchymal fibroelastosis (10%), interstitial pneumonia with autoimmune features (7%), an idiopathic interstitial pneumonia (4%) and connective tissue disease-related interstitial fibrosis (3%). 27540018 2016
Entrez Id: 5073
Gene Symbol: PARN
PARN
0.310 Biomarker disease BEFREE Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about similarities or differences of affected individuals.115 patients with mutations in telomerase reverse transcriptase (TERT) (n=75), telomerase RNA component (TERC) (n=7), regulator of telomere elongation helicase 1 (RTEL1) (n=14) and poly(A)-specific ribonuclease (PARN) (n=19) were identified and clinical data were analysed.Approximately one-half (46%) had a multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF); others had unclassifiable lung fibrosis (20%), chronic hypersensitivity pneumonitis (12%), pleuroparenchymal fibroelastosis (10%), interstitial pneumonia with autoimmune features (7%), an idiopathic interstitial pneumonia (4%) and connective tissue disease-related interstitial fibrosis (3%). 27540018 2016
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.310 GeneticVariation disease BEFREE Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about similarities or differences of affected individuals.115 patients with mutations in telomerase reverse transcriptase (TERT) (n=75), telomerase RNA component (TERC) (n=7), regulator of telomere elongation helicase 1 (RTEL1) (n=14) and poly(A)-specific ribonuclease (PARN) (n=19) were identified and clinical data were analysed.Approximately one-half (46%) had a multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF); others had unclassifiable lung fibrosis (20%), chronic hypersensitivity pneumonitis (12%), pleuroparenchymal fibroelastosis (10%), interstitial pneumonia with autoimmune features (7%), an idiopathic interstitial pneumonia (4%) and connective tissue disease-related interstitial fibrosis (3%). 27540018 2016
Entrez Id: 7012
Gene Symbol: TERC
TERC
0.310 Biomarker disease BEFREE Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about similarities or differences of affected individuals.115 patients with mutations in telomerase reverse transcriptase (TERT) (n=75), telomerase RNA component (TERC) (n=7), regulator of telomere elongation helicase 1 (RTEL1) (n=14) and poly(A)-specific ribonuclease (PARN) (n=19) were identified and clinical data were analysed.Approximately one-half (46%) had a multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF); others had unclassifiable lung fibrosis (20%), chronic hypersensitivity pneumonitis (12%), pleuroparenchymal fibroelastosis (10%), interstitial pneumonia with autoimmune features (7%), an idiopathic interstitial pneumonia (4%) and connective tissue disease-related interstitial fibrosis (3%). 27540018 2016
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.030 AlteredExpression disease BEFREE Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia. 15113854 2004
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.030 Biomarker disease BEFREE We correlated the transcription of TGF-beta(1), connective tissue growth factor (CTGF), IL-4, IL-13 and interferon-gamma (IFN-gamma) with lung function development in progressive fibrosis in idiopathic interstitial pneumonia. 18525195 2008
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.030 AlteredExpression disease BEFREE Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. 15161635 2004
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.020 Biomarker disease BEFREE We correlated the transcription of TGF-beta(1), connective tissue growth factor (CTGF), IL-4, IL-13 and interferon-gamma (IFN-gamma) with lung function development in progressive fibrosis in idiopathic interstitial pneumonia. 18525195 2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.020 Biomarker disease BEFREE We suggest that IL-8 is a key factor in the pathogenesis of fibrosing alveolitis and that the poorer prognosis of CFA compared with FASSc is related to higher levels of IL-8 within the lower respiratory tract. 7735620 1995
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.020 Biomarker disease BEFREE STAT4 and IRF5 act with additive effects in terms of susceptibility to both SSc and SSc-related fibrosing alveolitis. 19644887 2009
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.020 AlteredExpression disease BEFREE Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia. 15113854 2004
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.020 Biomarker disease BEFREE To search for single-nucleotide polymorphisms in the interleukin-8 (IL-8) and IL-8 receptor CXCR-1 and CXCR-2 genes, and to compare their distribution among patients with systemic sclerosis (SSc) with fibrosing alveolitis (FASSc) or without fibrosing alveolitis (NFASSc), or patients with cryptogenic fibrosing alveolitis (CFA), and normal healthy subjects. 10902769 2000
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.020 GeneticVariation disease BEFREE In a multivariate analysis model including the diffuse cutaneous subtype of SSc and positivity for anti-topoisomerase I antibodies, the IRF5 rs2004640 TT genotype remained associated with fibrosing alveolitis (P=0.029, OR 1.92, 95% CI 1.07-3.44). 19116937 2009
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.010 GeneticVariation disease BEFREE We found that the distribution of PAI-1 genotypes in the idiopathic interstitial pneumonia population was similar to that of a large control population. 12765340 2003
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.010 AlteredExpression disease BEFREE The purposes of the present study are to report the frequency and distribution of HNF4α-expressing cells at the different airway levels, and to investigate the potential significance of the expression of HNF4α in the histogenesis of non-TRU LADC with a special reference to the relationship to bronchiolar metaplasia in idiopathic interstitial pneumonia. 30848476 2019
Entrez Id: 84549
Gene Symbol: MAK16
MAK16
0.010 Biomarker disease BEFREE Anti-RNA binding protein positivity in idiopathic interstitial pneumonia. 30665514 2019
Entrez Id: 1116
Gene Symbol: CHI3L1
CHI3L1
0.010 Biomarker disease BEFREE YKL-40, a chitinase-like protein mainly secreted by macrophages, neutrophils and epithelial cells, is increased in patients with idiopathic interstitial pneumonia and sarcoidosis. 27836954 2017
Entrez Id: 6385
Gene Symbol: SDC4
SDC4
0.010 AlteredExpression disease BEFREE Serum syndecan-4 levels were significantly lower in patients with acute exacerbation of idiopathic interstitial pneumonia than in patients in the clinically stable phase. 28467516 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.010 AlteredExpression disease BEFREE Interestingly, atypical alveolar epithelium, which associates with asbestosis and idiopathic fibrosing alveolitis and is considered to be a precursor lesion for lung cancer, expressed the Cox-2 protein. 9823297 1998
Entrez Id: 943
Gene Symbol: TNFRSF8
TNFRSF8
0.010 AlteredExpression disease BEFREE A patient with fibrosing alveolitis developed a diffuse large B-cell (DLBC) lymphoma that expressed CD20 and CD30. 15257558 2004
Entrez Id: 931
Gene Symbol: MS4A1
MS4A1
0.010 AlteredExpression disease BEFREE A patient with fibrosing alveolitis developed a diffuse large B-cell (DLBC) lymphoma that expressed CD20 and CD30. 15257558 2004
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.010 Biomarker disease BEFREE We correlated the transcription of TGF-beta(1), connective tissue growth factor (CTGF), IL-4, IL-13 and interferon-gamma (IFN-gamma) with lung function development in progressive fibrosis in idiopathic interstitial pneumonia. 18525195 2008