| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.570 | AlteredExpression | disease | BEFREE | It summarizes risk factors for rituximab-induced hypogammaglobulinemia, such as preexisting low immunoglobulin G levels, CD19 levels, host factors, and additive effect of all immunomodulatory drugs used. | 30466771 | 2019 | ||||
|
0.570 | Biomarker | disease | BEFREE | This treatment also results in depletion of normal CD19+ B cells and is associated with hypogammaglobulinemia. | 31416717 | 2019 | ||||
|
0.570 | GeneticVariation | disease | BEFREE | Although CD19-targeted agents (blinatumomab or inebilizumab) are not associated with an increased risk of infection, they may cause IgG hypogammaglobulinaemia and neutropenia. | 29447988 | 2018 | ||||
|
0.570 | Biomarker | disease | BEFREE | Laboratory testing confirmed hypogammaglobulinemia with normal CD19, but failed to confirm a definitive diagnosis for targeted treatment decisions. | 29230214 | 2017 | ||||
|
0.570 | Biomarker | disease | GENOMICS_ENGLAND | Defects in the CD19 complex predispose to glomerulonephritis, as well as IgG1 subclass deficiency. | 21159371 | 2011 | ||||
|
0.570 | GeneticVariation | disease | BEFREE | Mutation of the CD19 gene causes a type of hypogammaglobulinemia in which the response of mature B cells to antigenic stimulation is defective. | 16672701 | 2006 | ||||
|
0.570 | Biomarker | disease | CTD_human | Mutation of the CD19 gene causes a type of hypogammaglobulinemia in which the response of mature B cells to antigenic stimulation is defective. | 16672701 | 2006 | ||||
|
0.570 | AlteredExpression | disease | BEFREE | In mice, CD19 deficiency and overexpression were shown to result in hypogammaglobulinemia and autoantibody production, respectively. | 12215898 | 2002 | ||||
|
0.570 | Biomarker | disease | BEFREE | Serum levels of sCR2 of patients with hypogammaglobulinaemia were not significantly different from those of normal individuals even in the case of two brothers with Bruton's X-linked agammaglobulinaemia (XLA) lacking (CD19+) B cells. | 1849806 | 1991 |