| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | As a panicogenic agent, CCK-4 is commonly used in clinic settings to induce panic attacks for the study of new anxiolytic drugs. | 30149298 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | This study demonstrated that in contrast to the findings in patients with panic disorder, in CCK-4-sensitive healthy volunteers the treatment with an antipanic SSRI did not cause a reduction of CCK-4-induced panic attacks beyond the effect of placebo. | 22939006 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | In humans, administration of CCK-4 reliably provokes panic attacks, which can be blocked by antipanic medication. | 22553078 | 2012 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Glyoxalase-I mRNA expression and CCK-4 induced panic attacks. | 20542521 | 2011 | ||||
|
0.090 | Biomarker | disease | BEFREE | None of the other candidate loci were significantly associated with CCK-4-induced panic attacks in healthy subjects. | 18832011 | 2008 | ||||
|
0.090 | Biomarker | disease | BEFREE | Specifically, there was a significantly lower rate of CCK-4-induced panic attacks in female subjects who had MAO-A longer alleles or 5-HTTLPR short allele gene variants. | 15346539 | 2004 | ||||
|
0.090 | Biomarker | disease | BEFREE | The tetrapeptide of cholecystokinin (CCK), CCK-4, is known to induce panic attacks in human subjects, while CCK-8 is reported to have a therapeutic effect on schizophrenia symptoms. | 11803530 | 2001 | ||||
|
0.090 | Biomarker | disease | BEFREE | Cholecystokinin tetrapeptide (CCK4) is known to induce panic attacks in patients with panic disorder at a lower dose than in normal controls. | 8837709 | 1996 | ||||
|
0.090 | Biomarker | disease | BEFREE | The hypothesis was supported by demonstrations that CCK-tetrapeptide (CCK4) induces panic attacks in humans. | 8104032 | 1993 |