Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 653361
Gene Symbol: NCF1
NCF1
0.300 Biomarker disease CTD_human A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases. 28135245 2017
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.300 Biomarker disease CTD_human A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
Entrez Id: 2212
Gene Symbol: FCGR2A
FCGR2A
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 134728
Gene Symbol: IRAK1BP1
IRAK1BP1
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.300 Biomarker disease CTD_human A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
Entrez Id: 1609
Gene Symbol: DGKQ
DGKQ
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 639
Gene Symbol: PRDM1
PRDM1
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I
0.300 Biomarker disease CTD_human A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
Entrez Id: 10318
Gene Symbol: TNIP1
TNIP1
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 9232
Gene Symbol: PTTG1
PTTG1
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 3592
Gene Symbol: IL12A
IL12A
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 55023
Gene Symbol: PHIP
PHIP
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 50618
Gene Symbol: ITSN2
ITSN2
0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.250 AlteredExpression disease BEFREE Human corneal epithelial cells (HCE-T cells) were treated with recombinant human CTSS at activity comparable to that in SS patient tears for 2, 4, 8, and 24 h. Acute CTSS significantly increased HCE-T cell gene and protein expression of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) from 2 to 4 h, while matrix metalloproteinase 9 (MMP-9), CTSS, and protease-activated receptor-2 (PAR-2) were increased by chronic CTSS (24 h). 30423938 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.250 Biomarker disease BEFREE The CPG committee strongly discouraged the use of tumor necrosis factor inhibitors for sicca symptoms and for the majority of clinical contexts in primary Sjögren's syndrome. 27390247 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.250 AlteredExpression disease BEFREE Deficiency in endothelial autophagy also increased TNF-α-induced inflammation under high-SS conditions and decreased expression of the antiinflammatory factor KLF-2. 28973855 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.250 Biomarker disease BEFREE However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1. 26904697 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.250 Therapeutic disease RGD [Astragalus polysaccharides improved the cardiac function in Sjögren's syndrome model rats based on keap 1-Nrf2/ARE signaling pathway: a mechanism exploration]. 24941846 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.250 Biomarker disease BEFREE Tumor necrosis factor-alpha is undetectable in the plasma of SS patients with elevated Hb F. 10814986 2000
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.220 GeneticVariation disease BEFREE BAFF variants have been also found to confer increased risk for subclinical atherosclerosis and lymphoma development in Sjogren's syndrome (SS) patients. 31444033 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.220 Biomarker disease BEFREE To identify independent contributors of fatigue in primary Sjögren's syndrome (SS) patients, taking into account clinical, laboratory, and psychological features, and to explore the potential role of interferon (IFN)-induced gene indoleamine 2,3-dioxygenase (IDO-1), anti-21-hydroxylase (anti-21[OH]) antibodies, and soluble BAFF. 26315379 2016
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.220 Biomarker disease MGD
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.210 AlteredExpression disease BEFREE We confirmed that TGF-β1 expression in ECs could influence SMC phenotypic change under SS conditions and that TGF-β1 expression in ECs could also change MMP-2 production but not MMP-9 production in SMCs under SS conditions in the co-culture model. 30707337 2019