×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
BEFREE
Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP.
29884332
2018
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
BEFREE
A recent genome-wide association study (GWAS) identified association with variants in X-linked CLDN2 and MORC4, and PRSS1-PRSS2 loci with chronic pancreatitis (CP ) in North American patients of European ancestry.
26820620
2016
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
BEFREE
In this study, we evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic RAP and CP .
26110235
2015
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
BEFREE
A genome-wide association study reported an association of chronic pancreatitis (CP ) with variants in PRSS1-PRSS2 (rs10273639 ; near the gene encoding cationic trypsinogen) and CLDN2-MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4).
25253127
2015
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
BEFREE
However mutations in cationic and anionic trypsinogen gene do not play an important role in causing CP in Asia Pacific region.
21323990
2011
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
BEFREE
It has been recently shown that a loss-of-function variant, c.571G>A (p.G191R ), in the anionic trypsinogen (PRSS2 ) gene protects against chronic pancreatitis in European populations.
19052022
2009
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
LHGDN
A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis.
18362849
2008
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
Biomarker
disease
CTD_human
Hereditary chronic pancreatitis.
18206817
2008
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
Biomarker
disease
CTD_human
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
16699518
2006
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
AlteredExpression
disease
LHGDN
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
16699518
2006
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
BEFREE
In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis .
16699518
2006
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
LHGDN
Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.
15776435
2005
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
GeneticVariation
disease
BEFREE
Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.
15776435
2005
×
Entrez Id:
5645
Gene Symbol:
PRSS2
PRSS2
0.490
Biomarker
disease
HPO