Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE An interaction effect between EBV infection and HLA-DRB1*1501 on MS was observed on the additive scale (S, 1.43; 95%CI, 1.05-1.95, P = 0.023), but no interaction effect was observed on the multiplicative scale (OR, 0.86, 95%CI, 0.59-1.26). 26656273 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Multiple mechanisms in different disease stages are responsible for immunopathology in MS. HLA Class II DR2b (DRB1*1501 β, DRA1*0101 α) is the strongest genetic risk factor for MS. Remnants of ancient retroviruses in the human genome, termed human endogenous retroviruses (HERV), and Epstein-Barr virus (EBV) infection are also associated with MS. 31689443 2020
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Since HLA-DR was recently described as a co-receptor for EBV infection of B cells, we also determined HLA-DRB1 alleles in the EBV- group. 10361236 1999
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Our study suggests that MS patients harboring DRB1*0405, a genetic risk factor for MS in the Japanese population, have a younger age at onset and a relatively benign disease course, while DRB1*0405-negative MS patients have features similar to Western-type MS in terms of association with Epstein-Barr virus infection and DRB1*1501. 23152786 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE One of the main risk factors, also confirmed in pediatric MS, is HLA DRB1*1501 In addition to genetic factors, a large part of disease susceptibility in adults is conferred by environmental risk factors such as low vitamin D status, exposure to cigarette smoking, and remote Epstein-Barr virus (EBV) infection. 27572857 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE To determine the association of EBV infection with MS incidence, and to investigate HLA-DRB1*1501 as a potential genetic risk factor for MS in Kuwait. 26198919 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE The effect of remote EBV infection on the risk of pediatric MS depended on race and <i>HLA-DRB1*15:01</i> status. 30349857 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection. 15288002 2004
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 GeneticVariation group GWASDB A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). 23326239 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 GeneticVariation group GWASCAT A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). 23326239 2013
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.110 GeneticVariation group GWASDB A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). 23326239 2013
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.110 GeneticVariation group BEFREE The aims of this study were to detect the presence of Epstein-Barr virus DNA (EBV-DNA) in peripheral blood of NPC patients, to molecularly define human leukocyte antigens (HLA) DRB1*, DQA1* and DQB1* allele frequencies, and, finally, to determine whether the genetic predisposition of an individual to NPC depends on the liability to EBV infection. 18535809 2008
Entrez Id: 1380
Gene Symbol: CR2
CR2
0.100 Biomarker group BEFREE Group I Burkitt's lymphoma cell lines conditionally expressing the CD21 receptor for EBV infection were superinfected with EBV. 7856099 1995
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 AlteredExpression group BEFREE EBV infection and LMP-1 induced CCL20 mRNA expression in the EBV-negative Burkitt lymphoma (BL) cell lines and the embryonic kidney cell line. 16409294 2006
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 Biomarker group BEFREE Tissues from 150 patients were also analyzed for the presence of latent EBV infection using in situ hybridization for EBV-encoded RNA (EBER) and immunohistochemistry for latent membrane protein (LMP1). 21143522 2011
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 GeneticVariation group BEFREE Fifty-two monoclonal PTLD were investigated for: 1). somatic hypermutation of IgV genes by direct sequencing of IgV rearrangements; 2). expression of BCL6, MUM1 and CD138 proteins by immunohistochemistry; 3). aberrant hypermethylation of DAP-kinase gene by methylation-specific polymerase chain reaction (PCR); 4). genotypic characterization of Epstein Barr virus (EBV) in EBV infected PTLD by PCR analysis of the prevalence of deletions in the carboxyterminal portion of the LMP1 gene and for the definition of type-1/type-2 EBV infection. 15041926 2004
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 GeneticVariation group BEFREE As oral cavity is the main location of Epstein-Barr virus (EBV) latency and shedding, and as EBV-encoded latent membrane protein-1 (LMP-1) has a crucial role in cell transformation, association between EBV infection, LMP-1 expression and oral malignancy is of interest. 31291930 2019
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.100 GeneticVariation group BEFREE Patients with the primary immunodeficiency X-linked lymphoproliferative disease (XLP), which is caused by mutations in SH2D1A, are highly susceptible to Epstein-Barr virus (EBV) infection. 22493517 2012
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 AlteredExpression group BEFREE EBV infection is associated with c-met abnormal expression but not with c-myc protein in EBVaGC. c-met overexpression is not induced by LMP1. 16609989 2006
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.100 Biomarker group BEFREE This rare disorder of immunedysregulation presents typically after Epstein-Barr virus infection and results from defects in the SAP (SLAM associated protein) gene. 15320910 2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression group BEFREE Epstein-Barr virus infection and bcl-2 proto-oncogene expression. Separate events in the pathogenesis of Hodgkin's disease? 8238244 1993
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker group BEFREE Because human and viral IL-10 are likely to be induced during acute EBV infection and display a variety of functions on human T cells, we examined IL-10 effects on infectious mononucleosis T cell death. 8040267 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker group BEFREE Specifically, 6 of 11 EBV-positive carcinomas had accumulation of p53 protein by immunohistochemical analysis, which was similar to the prevalence of p53 accumulation in EBV-negative specimens and suggests that EBV infection does not substitute for p53 mutations during tumorigenesis. 8543306 1996
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker group BEFREE Although Epstein-Barr virus (EBV) infection and MYC translocations are hallmarks of the disease, it is unclear whether other factors may contribute to its development. 26468873 2015
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.100 Biomarker group BEFREE The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) syndrome, a rare genetic disorder characterized by abnormal responses to Epstein-Barr virus infection, lymphoproliferative syndromes, and dysgammaglobulinemia. 21219180 2011