Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.020 Biomarker group BEFREE In contrast, stimulator cells with no shared HLA-DR or without evidence of EBV infection never induced IL-2 release. 2992857 1985
Entrez Id: 1380
Gene Symbol: CR2
CR2
0.100 Biomarker group BEFREE Hairy cells are not readily susceptible to EBV infection in vitro, even though they are EBV receptor-positive B cells. 2823016 1987
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation group BEFREE These studies suggest that both the deregulation of MYC transcription and the chromosomal rearrangement in the region of the MYC locus in this B-cell line may have occurred as a result of EBV infection. 3039510 1987
Entrez Id: 6741
Gene Symbol: SSB
SSB
0.010 Biomarker group BEFREE It is proposed that during EBV infection, there are multiple copies of the EBERs available to bind to the La ribonucleoprotein and when infection occurs in subjects who have an impaired T cell-mediated response to EBV, and who are genetically predisposed to autoimmunity, there is loss of immunological tolerance to La with production of anti-La (SS-B). 3035352 1987
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 Biomarker group BEFREE Interferon-gamma in a family with X-linked lymphoproliferative syndrome with acute Epstein-Barr virus infection. 2539385 1989
Entrez Id: 968
Gene Symbol: CD68
CD68
0.050 Biomarker group BEFREE Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant. 2472638 1989
Entrez Id: 11047
Gene Symbol: ADRM1
ADRM1
0.040 Biomarker group BEFREE Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant. 2472638 1989
Entrez Id: 2268
Gene Symbol: FGR
FGR
0.010 Biomarker group BEFREE In order to assess the generality of a role for the c-fgr gene in the response of B-lymphocytes to EBV-infection, which is controversial, we have analysed c-fgr expression in 6 freshly immortalized cell lines established by EBV (B95-8) infection of B-lymphocytes from the peripheral blood of normal adults and of adults with rheumatoid arthritis, from cord blood, and from foetal liver. 2154410 1990
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.100 GeneticVariation group BEFREE The recent use of DNA restriction fragment length polymorphism (RFLP) probes in linkage with the XLP gene now permit detection of affected males prior to primary EBV infection. 1683154 1991
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.100 GeneticVariation group BEFREE We summarized recent research findings and technological advances that permit accurate diagnosis of carrier females and detection of males with the XLP gene before Epstein-Barr virus infection. 1847089 1991
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation group BEFREE Similar to endemic and sporadic Burkitt's lymphoma, monoclonal B-lymphoma subsets were found to be infected with Epstein-Barr virus (EBV) or have c-myc gene rearrangements, suggesting a role for EBV infection or chromosomal translocation in a subset of AIDS NHLs. 2022596 1991
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.030 Biomarker group BEFREE We show that EBV termini are uniformly clonal in sBL, eBL, and AIDS-NHL, strongly suggesting that EBV infection has preceded and, thus, most likely contributed to clonal expansion in these malignancies. 1847310 1991
Entrez Id: 389493
Gene Symbol: NUPR2
NUPR2
0.010 AlteredExpression group BEFREE Nuclear protein-2 (EBNA-2) and EBNA-leader protein (-LP) were detected by 12 hr, and by 32 hr were at the levels of stable EBV infection in lymphoblastoid cell lines (LCLs). 1849678 1991
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.030 Biomarker group BEFREE This study confirms the relatively low frequency of EBV infection in systemic AIDS-NHL in general, but reinforces the notion that EBV may be required for the pathogenesis of AIDS-LC-IBP, as recently suggested by the high frequency of EBV positivity in primary CNS AIDS-NHL which are mostly represented by LC-IBP (2). 1325169 1992
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.020 Biomarker group BEFREE Therefore, an HBL-5 phenotype with expression of CD54 and LMP tends toward an LCL phenotype, and the augmentation of CD54 on the HBL-5 cells in comparison with primary lymphoma cells is likely to be upregulated by LMP, probably resulting from the EBV infection. 1309680 1992
Entrez Id: 3956
Gene Symbol: LGALS1
LGALS1
0.020 Biomarker group BEFREE Therefore, an HBL-5 phenotype with expression of CD54 and LMP tends toward an LCL phenotype, and the augmentation of CD54 on the HBL-5 cells in comparison with primary lymphoma cells is likely to be upregulated by LMP, probably resulting from the EBV infection. 1309680 1992
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.010 AlteredExpression group BEFREE We conclude that some AIDS-related lymphomas are associated with eosinophilia and that the eosinophilia may be related to EBV infection and transcriptional activation of the IL-5 gene. 1334944 1992
Entrez Id: 966
Gene Symbol: CD59
CD59
0.010 Biomarker group BEFREE We established a cultured cell line (NCU1) which is HRF20 deficient from the patient's lymphocytes by Epstein-Barr-virus (EBV) infection. 1382994 1992
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression group BEFREE Epstein-Barr virus infection and bcl-2 proto-oncogene expression. Separate events in the pathogenesis of Hodgkin's disease? 8238244 1993
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 Biomarker group BEFREE Expression of EBNA1, EBNA2, EBNA3A, EBNA3C, and LMP1 and permissivity for lytic EBV infection were also unaffected by the LMP2 deletion mutation. 8392630 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression group BEFREE While a more detailed analysis of the p53 gene in HD is required, these data show that overexpression of p53 in HD is heterogeneous and that there is no simple correlation between EBV infection and p53 overexpression. 8383196 1993
Entrez Id: 1380
Gene Symbol: CR2
CR2
0.100 Biomarker group BEFREE Two of these, the genes for CD21 and vimentin, were previously known to be induced by EBV infection. 8383238 1993
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.100 GeneticVariation group BEFREE Given that 50% of males inheriting the defective XLP gene die following primary EBV infection, it is vital that they be identified pre-EBV infection. 8256804 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression group BEFREE Thus, there appears to be no correlation of p53 overexpression with EBV infection. 8410495 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation group BEFREE These lesions are not uniformly distributed, but, rather, cluster with specific types of AIDS-NHL: EBV infection is preferentially associated with LC-IBPL (4/4; 100%), while it is present in only a fraction of SNCCL (5/16; 31.2%) and LNCCL (1/4; 25%); c-myc oncogene activation clusters with SNCCL (16/16; 100%), whereas it is less frequent in LC-IBPL (1/4; 25%) and LNCCL (2/4; 50%); p53 inactivation is restricted to SNCCL (10/16; 62.5%) and consistently associated with c-myc activation. 8380252 1993