Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 Biomarker group BEFREE These data suggest new functions of the N terminus and transmembrane domains in LMP1 intra- and extracellular trafficking that are likely downstream of an interaction with CD63.<b>IMPORTANCE</b> EBV infection contributes to the development of cancers, such as nasopharyngeal carcinoma, Burkitt lymphoma, Hodgkin's disease, and posttransplant lymphomas, in immunocompromised or genetically susceptible individuals. 29950415 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE PD-L1/L2 overexpression is caused by gene amplification at the 9p24.1 locus and/or latent Epstein-Barr virus infection present in around 40% of cHL cases. 29915720 2018
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 Biomarker group BEFREE In the context of Epstein-Barr virus (EBV) infection, CD63 is required for the efficient packaging of the major viral oncoprotein latent membrane protein 1 (LMP1) into exosomes and other EV populations and acts as a negative regulator of LMP1 intracellular signaling. 29212935 2018
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 AlteredExpression group BEFREE Recent evidence has shown that the Epstein-Barr virus (EBV) oncogene LMP1 is not expressed at high levels early after EBV infection of primary B cells, despite its being essential for the long-term outgrowth of immortalized lymphoblastoid cell lines (LCLs). 29118124 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE EBV infection was associated with the number of CD3+ T cells (OR = 2.91 95% CI 1.27-6.68, <i>p</i> = 0.012) and PD-L1 expression in TME (OR = 2.57, 95% CI 1.13-5.82, <i>p</i> = 0.024). 29552300 2018
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 AlteredExpression group BEFREE LMP1 is expressed in EBV-infected germinal center (GC) B cells of immunocompetent individuals, suggesting that it may contribute to persistent EBV infection. 30137504 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker group BEFREE While nodal RS has been extensively investigated in literature, pathogenesis and prognosis of cutaneous RS are still partially unknown, even if a role of Epstein-Barr virus infection and p53 disruption has been suggested. 27400669 2017
Entrez Id: 100506866
Gene Symbol: TTN-AS1
TTN-AS1
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker group BEFREE The incidence of EBV infections significantly correlated with the subtypes and with TP53, CDKN2A, and CDKN2B. 28581676 2017
Entrez Id: 27123
Gene Symbol: DKK2
DKK2
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017
Entrez Id: 10718
Gene Symbol: NRG3
NRG3
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017
Entrez Id: 55356
Gene Symbol: SLC22A15
SLC22A15
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE PD-L1 expression in tumor cells can be induced by extrinsic signal (i.e. interferon gamma) or intrinsic signals, such as genetic aberrations involving 9p24.1, latent Epstein-Barr virus infection, PD-L1 3'- untranslated region disruptions, and activated Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. 28242522 2017
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 Biomarker group BEFREE Our findings help to elucidate the still enigmatic link between EBV infection and MS development, suggesting that myelin-reactive antibodies raised as a response toward EBV protein LMP1 are not truly cross-reactive but are primarily caused by epitope spreading. 28729867 2017
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 AlteredExpression group BEFREE We show that EBV infection or ectopic expression of the EBV-encoded latent genes (EBNA1, LMP1, and LMP2A) can up-regulate sphingosine kinase 1 (SPHK1), the key enzyme that produces S1P, in NPC cell lines. 28240350 2017
Entrez Id: 1380
Gene Symbol: CR2
CR2
0.100 Biomarker group BEFREE Anti-CD21 antibody inhibited in vitro infection of EBV, suggesting that CD21 plays a role in EBV infection into WILL4 cells. 28110206 2017
Entrez Id: 5460
Gene Symbol: POU5F1
POU5F1
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017
Entrez Id: 140733
Gene Symbol: MACROD2
MACROD2
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 AlteredExpression group BEFREE However, during early infection EBV induces rapid B cell proliferation with low levels of LMP1 and little apoptosis. 28425914 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker group BEFREE Although its exact etiology is poorly understood, Epstein-Barr virus infection and MYC gene aberrations have been implicated in its development in both HIV-positive and HIV-negative patients. 27900846 2017
Entrez Id: 100507175
Gene Symbol: LINC02408
LINC02408
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker group BEFREE The mutual regulation between p53 and LMP1 may play an important role in EBV infection and latency and its related cancers.<b>IMPORTANCE</b> The tumor suppressor p53 is a critical cellular protein in response to various stresses and dictates cells for various responses, including apoptosis. 28794023 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 AlteredExpression group BEFREE Cytokine and chemokine transcripts expression and immunophenotype analysis showed that EBV infection was associated with increased gene expression of immunosuppressive cytokine (IL-10) together with increased CD8+ T-cells and granzyme B+ cytotoxic effector cells. 28883511 2017
Entrez Id: 148641
Gene Symbol: SLC35F3
SLC35F3
0.100 GeneticVariation group GWASCAT Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples. 28654678 2017