Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Host cell transcriptional changes in response to EBV infection classified tumors into two molecular subtypes based on patterns of IFN signature genes and immune checkpoint markers, such as PD-L1 and IDO1. 31481499 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE The numbers of EBER+PD-L1+ cells were directly correlated with the numbers of EBER+CD3+ and EBER+CD8+ cells suggesting a possible role for PD-L1 in EBV infection of T-cells. 30842768 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE We analyzed the outcome of 30 relapsed or refractory NHL patients treated with pembrolizumab, and compared the outcome between Epstein-Barr virus (EBV)‒positive and negative subtypes because EBV infection of tumor cells can upregulate PDL1 expression. 30025443 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE PD-L1/L2 overexpression is caused by gene amplification at the 9p24.1 locus and/or latent Epstein-Barr virus infection present in around 40% of cHL cases. 29915720 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE EBV infection was associated with the number of CD3+ T cells (OR = 2.91 95% CI 1.27-6.68, <i>p</i> = 0.012) and PD-L1 expression in TME (OR = 2.57, 95% CI 1.13-5.82, <i>p</i> = 0.024). 29552300 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE PD-L1 expression in tumor cells can be induced by extrinsic signal (i.e. interferon gamma) or intrinsic signals, such as genetic aberrations involving 9p24.1, latent Epstein-Barr virus infection, PD-L1 3'- untranslated region disruptions, and activated Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. 28242522 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE These include primary mediastinal B cell lymphoma, primary central nervous system lymphoma, and primary testicular lymphoma, which harbor frequent alterations in 9p24.1, as well as Epstein Barr virus (EBV)-infected lymphomas, where EBV infection leads to increased PD-L1 expression. 29296917 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE Low GMS was a manifestation of better prognosis and inflammatory tumor microenvironment, which was related to MMR deficiency (P = 0.042) and EBV infection (P = 0.032), and within this microenvironment, expression of PD-L1 in carcinoma cells (P = 0.030) or in inflammatory cells (P = 0.029) was significantly higher. 28180998 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE In addition to the above, subgroup analysis showed that GC patients with deeper tumor infiltration, positive lymph-node metastasis, positive venous invasion, Epstein-Barr virus infection positive (EBV+), Microsatellite Instability (MSI) are more likely to expression PD-L1. 28796808 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE In lymphoid neoplasms, aberrations in 9p24.1 (PD-L1, PD-L2, and JAK2 locus), latent Epstein-Barr virus infection, PD-L1 3'-untranslated region disruption, and constitutive JAK-STAT pathway are known mechanisms to induce PD-L1 expression in lymphoma cells. 28482851 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE The 5-year overall survival (OS) was evaluated according to EBV infection, T-cell subsets, PD-1 and PD-L1 expression and immune types. 28978018 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE In univariate analysis, PD-L1 expression was significantly associated with GC-MLI (P<.001), lower age (P=.019), EBV infection (P<.001), lower HER2 expression (P=.011), and diffuse/mixed type of histology (P=.022). 27260946 2016
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE PD-L1+/EBV+ and PD-L1+/MSI cancers had significantly more CD8 T cells at tumor invasive front than PD-L1+/EBV-/MSS cancers (P<0.001). 27465786 2016
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE In addition, we defined Epstein-Barr virus (EBV) infection as an alternative mechanism for PD-L1 induction in cHLs with diploid 9p24.1. 22271878 2012